Motif ID: MSX2

Z-value: 0.597


Transcription factors associated with MSX2:

Gene SymbolEntrez IDGene Name
MSX2 ENSG00000120149.7 MSX2



Activity profile for motif MSX2.

activity profile for motif MSX2


Sorted Z-values histogram for motif MSX2

Sorted Z-values for motif MSX2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_151965048 1.785 ENST00000368809.1
 S100A10
S100 calcium binding protein A10
chr1_-_68698222 1.119 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS



wntless Wnt ligand secretion mediator



chr6_-_167040731 1.017 ENST00000265678.4
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_94050668 0.891 ENST00000539242.1
 BCAR3
breast cancer anti-estrogen resistance 3
chr3_-_151034734 0.776 ENST00000260843.4
 GPR87
G protein-coupled receptor 87
chr1_-_68698197 0.662 ENST00000370973.2
ENST00000370971.1
 WLS

wntless Wnt ligand secretion mediator

chr12_-_10022735 0.599 ENST00000228438.2
 CLEC2B
C-type lectin domain family 2, member B
chrX_-_48931648 0.482 ENST00000376386.3
ENST00000376390.4
 PRAF2

PRA1 domain family, member 2

chr12_+_9102632 0.469 ENST00000539240.1
 KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr3_-_112127981 0.468 ENST00000486726.2
 RP11-231E6.1
RP11-231E6.1
chr5_+_95997918 0.466 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST



calpastatin



chr7_+_134331550 0.447 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
 BPGM


2,3-bisphosphoglycerate mutase


chr6_-_111927449 0.398 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2


TRAF3 interacting protein 2


chr5_+_66254698 0.378 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
 MAST4


microtubule associated serine/threonine kinase family member 4


chr5_+_95998070 0.367 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
 CAST


calpastatin


chr5_+_140797296 0.352 ENST00000398594.2
 PCDHGB7
protocadherin gamma subfamily B, 7
chr10_-_99447024 0.351 ENST00000370626.3
 AVPI1
arginine vasopressin-induced 1
chr15_+_41245160 0.347 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr7_-_2883928 0.330 ENST00000275364.3
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr6_-_111927062 0.326 ENST00000359831.4
 TRAF3IP2
TRAF3 interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.4 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.1 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.1 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.1 GO:1902414 protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0006379 mRNA cleavage(GO:0006379)

Gene overrepresentation in cellular_component category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.4 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway