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ENCODE cell lines, expression (Ernst 2011)
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Results for BPTF
Z-value: 1.52
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Transcription factors associated with BPTF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BPTF | hg19_v2_chr17_+_65821780_65821826 | 0.17 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BPTF
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_2709906 | 4.32 |
ENST00000430575.1 |
RPS4Y1 |
ribosomal protein S4, Y-linked 1 |
| chr11_+_114168085 | 3.50 |
ENST00000541754.1 |
NNMT |
nicotinamide N-methyltransferase |
| chr7_-_150329421 | 3.19 |
ENST00000493969.1 ENST00000328902.5 |
GIMAP6 |
GTPase, IMAP family member 6 |
| chr11_+_114128522 | 2.44 |
ENST00000535401.1 |
NNMT |
nicotinamide N-methyltransferase |
| chr1_+_151030234 | 2.25 |
ENST00000368921.3 |
MLLT11 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| chr4_-_186877806 | 2.18 |
ENST00000355634.5 |
SORBS2 |
sorbin and SH3 domain containing 2 |
| chr17_-_62097927 | 2.14 |
ENST00000578313.1 ENST00000584084.1 ENST00000579788.1 ENST00000579687.1 ENST00000578379.1 ENST00000578892.1 ENST00000412356.1 ENST00000418105.1 |
ICAM2 |
intercellular adhesion molecule 2 |
| chr12_+_75874984 | 1.93 |
ENST00000550491.1 |
GLIPR1 |
GLI pathogenesis-related 1 |
| chr17_-_62084241 | 1.91 |
ENST00000449662.2 |
ICAM2 |
intercellular adhesion molecule 2 |
| chr4_+_90823130 | 1.89 |
ENST00000508372.1 |
MMRN1 |
multimerin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.6 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 6.1 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.5 | 5.9 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 4.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 3.3 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 3.1 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.3 | 2.5 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.5 | 2.3 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.1 | 2.3 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.7 | 2.2 | GO:0010166 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 6.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 4.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 4.6 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 3.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 2.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 2.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 2.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 2.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 5.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 2.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.4 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 6.6 | GO:0019843 | rRNA binding(GO:0019843) |
| 1.5 | 5.9 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.0 | 4.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 3.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 2.5 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.7 | 2.2 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 2.1 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.7 | 2.0 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 0.1 | 2.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 6.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 4.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 4.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 3.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 2.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.6 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |