ISMARA results: CEBPA

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ENCODE cell lines, expression (Ernst 2011)

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Results for CEBPA

Z-value: 0.81

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Transcription factors associated with CEBPA

Gene Symbol	Gene ID	Gene Info
CEBPA Ensembl NCBI GeneCards UniProt	ENSG00000245848.2	CEBPA

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CEBPA	hg19_v2_chr19_-_33793430_33793470	0.65	6.9e-03	Click!

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_+_69742121	3.19	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ	lysozyme
chr4_-_155533787	2.61	ENST00000407946.1 ENST00000405164.1 ENST00000336098.3 ENST00000393846.2 ENST00000404648.3 ENST00000443553.1	FGG	fibrinogen gamma chain
chr3_-_148939835	2.35	ENST00000264613.6	CP	ceruloplasmin (ferroxidase)
chr19_-_6720686	2.34	ENST00000245907.6	C3	complement component 3
chr17_-_7018128	2.29	ENST00000380952.2 ENST00000254850.7	ASGR2	asialoglycoprotein receptor 2
chr17_-_7017968	2.27	ENST00000355035.5	ASGR2	asialoglycoprotein receptor 2
chr16_+_72088376	2.02	ENST00000570083.1 ENST00000355906.5 ENST00000398131.2 ENST00000569639.1 ENST00000564499.1 ENST00000357763.4 ENST00000562526.1 ENST00000565574.1 ENST00000568417.2 ENST00000356967.5	HP HPR	haptoglobin haptoglobin-related protein
chr19_-_48389651	1.95	ENST00000222002.3	SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_+_95078714	1.87	ENST00000393078.3 ENST00000393080.4 ENST00000467132.1	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr2_-_21266935	1.81	ENST00000233242.1	APOB	apolipoprotein B

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	4.6	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
1.0	4.0	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0	3.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	3.3	GO:0003796	lysozyme activity(GO:0003796)
0.1	3.0	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.3	2.4	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3	2.0	GO:0030492	hemoglobin binding(GO:0030492)
0.3	2.0	GO:0050294	steroid sulfotransferase activity(GO:0050294)
0.5	1.9	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)

Showing 1 to 10 of 98 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	7.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.5	3.7	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.2	2.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	2.4	GO:0001533	cornified envelope(GO:0001533)
0.5	2.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.9	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1	0.7	GO:0032432	stress fiber(GO:0001725) actin filament bundle(GO:0032432) contractile actin filament bundle(GO:0097517)
0.1	0.7	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.7	GO:0005719	nuclear euchromatin(GO:0005719)

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	2.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	2.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	2.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	2.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	2.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.9	PID E2F PATHWAY	E2F transcription factor network
0.0	1.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.6	PID BMP PATHWAY	BMP receptor signaling
0.0	1.6	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Showing 1 to 10 of 20 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.7	3.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.2	3.0	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.4	2.9	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.6	2.6	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2	2.5	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.1	2.4	GO:0006825	copper ion transport(GO:0006825)
0.8	2.3	GO:0001798	positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.7	2.0	GO:2000296	negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1	2.0	GO:0006706	steroid catabolic process(GO:0006706) sulfation(GO:0051923)

Showing 1 to 10 of 132 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.3	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	3.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	3.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	2.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	2.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	2.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	2.0	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	1.5	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	1.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	1.2	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors

Showing 1 to 10 of 32 entries

Results for CEBPA

Z-value: 0.81

Motif logo

Transcription factors associated with CEBPA

Activity-expression correlation:

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category: