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ENCODE cell lines, expression (Ernst 2011)
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Results for CEBPB
Z-value: 1.52
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.65 | 6.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_64216748 | 7.71 |
ENST00000585162.1 |
APOH |
apolipoprotein H (beta-2-glycoprotein I) |
| chr17_+_1665253 | 6.07 |
ENST00000254722.4 |
SERPINF1 |
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| chr17_+_1665345 | 5.26 |
ENST00000576406.1 ENST00000571149.1 |
SERPINF1 |
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| chr4_-_155533787 | 4.79 |
ENST00000407946.1 ENST00000405164.1 ENST00000336098.3 ENST00000393846.2 ENST00000404648.3 ENST00000443553.1 |
FGG |
fibrinogen gamma chain |
| chr2_-_216300784 | 4.24 |
ENST00000421182.1 ENST00000432072.2 ENST00000323926.6 ENST00000336916.4 ENST00000357867.4 ENST00000359671.1 ENST00000346544.3 ENST00000345488.5 ENST00000357009.2 ENST00000446046.1 ENST00000356005.4 ENST00000443816.1 ENST00000426059.1 ENST00000354785.4 |
FN1 |
fibronectin 1 |
| chr3_-_49722523 | 3.69 |
ENST00000448220.1 |
MST1 |
macrophage stimulating 1 (hepatocyte growth factor-like) |
| chr5_+_150400124 | 3.50 |
ENST00000388825.4 ENST00000521650.1 ENST00000517973.1 |
GPX3 |
glutathione peroxidase 3 (plasma) |
| chr5_-_172756506 | 3.35 |
ENST00000265087.4 |
STC2 |
stanniocalcin 2 |
| chr6_+_31895467 | 3.33 |
ENST00000556679.1 ENST00000456570.1 |
CFB CFB |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
| chr6_+_31895254 | 3.31 |
ENST00000299367.5 ENST00000442278.2 |
C2 |
complement component 2 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.9 | 11.3 | GO:0043203 | axon hillock(GO:0043203) |
| 0.8 | 9.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 7.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 7.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.4 | 4.3 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.0 | 3.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.4 | 3.5 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.4 | 2.8 | GO:0070552 | BRISC complex(GO:0070552) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 8.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 4.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.2 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 3.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 2.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 2.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.3 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.8 | 7.7 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.5 | 6.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 4.8 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 1.4 | 4.2 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.3 | 3.7 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 1.2 | 3.5 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.3 | 3.5 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 3.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.2 | 3.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.5 | 7.7 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.2 | 6.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 6.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 5.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 4.2 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 3.7 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.3 | 3.5 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 3.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 9.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 6.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 3.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 3.7 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 3.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |