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ENCODE cell lines, expression (Ernst 2011)
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Results for CEBPE_CEBPD
Z-value: 1.95
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | 0.48 | 5.9e-02 | Click! |
| CEBPE | hg19_v2_chr14_-_23588816_23588836 | 0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_186330712 | 7.60 |
ENST00000411641.2 ENST00000273784.5 |
AHSG |
alpha-2-HS-glycoprotein |
| chr19_-_6720686 | 7.53 |
ENST00000245907.6 |
C3 |
complement component 3 |
| chr8_-_27468842 | 6.98 |
ENST00000523500.1 |
CLU |
clusterin |
| chr3_-_148939835 | 6.88 |
ENST00000264613.6 |
CP |
ceruloplasmin (ferroxidase) |
| chr8_-_27468945 | 5.70 |
ENST00000405140.3 |
CLU |
clusterin |
| chr8_-_134309823 | 5.61 |
ENST00000414097.2 |
NDRG1 |
N-myc downstream regulated 1 |
| chr1_+_169079823 | 5.59 |
ENST00000367813.3 |
ATP1B1 |
ATPase, Na+/K+ transporting, beta 1 polypeptide |
| chrX_-_131547625 | 5.41 |
ENST00000394311.2 |
MBNL3 |
muscleblind-like splicing regulator 3 |
| chrX_-_131547596 | 5.34 |
ENST00000538204.1 ENST00000370849.3 |
MBNL3 |
muscleblind-like splicing regulator 3 |
| chr2_+_102721023 | 5.30 |
ENST00000409589.1 ENST00000409329.1 |
IL1R1 |
interleukin 1 receptor, type I |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.3 | 21.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 10.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 5.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.3 | 4.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 4.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 4.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.8 | 3.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.2 | 3.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 2.8 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.0 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 11.0 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.4 | 10.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 8.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.8 | 6.9 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 6.9 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 6.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 6.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.2 | 6.1 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 5.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 10.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 8.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 7.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 7.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 6.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 3.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 3.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 18.0 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.0 | 10.9 | GO:0090232 | peripheral nervous system myelin maintenance(GO:0032287) positive regulation of spindle checkpoint(GO:0090232) |
| 0.4 | 10.8 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.4 | 8.2 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.7 | 8.0 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 2.5 | 7.5 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.1 | 6.4 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.2 | 6.3 | GO:0006825 | copper ion transport(GO:0006825) |
| 1.5 | 5.8 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 1.4 | 5.6 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 21.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 20.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 6.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 5.9 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 5.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 4.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 4.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 3.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |