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ENCODE cell lines, expression (Ernst 2011)
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Results for CREB1
Z-value: 2.07
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg19_v2_chr2_+_208394455_208394471 | 0.27 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_43027105 | 3.54 |
ENST00000230413.5 ENST00000487429.1 ENST00000489623.1 ENST00000468957.1 |
MRPL2 |
mitochondrial ribosomal protein L2 |
| chr12_+_132628963 | 3.36 |
ENST00000330579.1 |
NOC4L |
nucleolar complex associated 4 homolog (S. cerevisiae) |
| chr18_-_268019 | 2.68 |
ENST00000261600.6 |
THOC1 |
THO complex 1 |
| chr3_+_45017722 | 2.56 |
ENST00000265564.7 |
EXOSC7 |
exosome component 7 |
| chr1_-_53704157 | 2.43 |
ENST00000371466.4 ENST00000371470.3 |
MAGOH |
mago-nashi homolog, proliferation-associated (Drosophila) |
| chr16_-_3767506 | 2.42 |
ENST00000538171.1 |
TRAP1 |
TNF receptor-associated protein 1 |
| chr3_+_185303962 | 2.42 |
ENST00000296257.5 |
SENP2 |
SUMO1/sentrin/SMT3 specific peptidase 2 |
| chr6_-_31774714 | 2.36 |
ENST00000375661.5 |
LSM2 |
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| chr3_+_185304059 | 2.29 |
ENST00000427465.2 |
SENP2 |
SUMO1/sentrin/SMT3 specific peptidase 2 |
| chr16_-_3767551 | 2.29 |
ENST00000246957.5 |
TRAP1 |
TNF receptor-associated protein 1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.1 | 4.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 4.1 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.4 | 3.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 3.1 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 2.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.6 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 2.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 2.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.3 | GO:0070283 | lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283) |
| 0.1 | 5.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 5.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 5.2 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 5.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 4.9 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 1.2 | 4.7 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 4.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 4.2 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.4 | 3.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 8.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 6.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 6.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 5.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 4.7 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 1.1 | 3.4 | GO:0030689 | Noc complex(GO:0030689) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 3.2 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.6 | 3.0 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 0.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 0.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 2.1 | 6.3 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
| 0.1 | 5.6 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.1 | 5.2 | GO:0031124 | mRNA 3'-end processing(GO:0031124) |
| 0.1 | 4.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.2 | 4.7 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.6 | 4.7 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 4.7 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.9 | 3.6 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.4 | 3.4 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |