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ENCODE cell lines, expression (Ernst 2011)
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Results for CUUUGGU
Z-value: 1.78
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miRNA associated with seed CUUUGGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-9-5p
|
MIMAT0000441 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUUUGGU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_135364584 | 6.00 |
ENST00000442011.2 ENST00000305126.8 |
TGFBI |
transforming growth factor, beta-induced, 68kDa |
| chr4_-_157892498 | 5.95 |
ENST00000502773.1 |
PDGFC |
platelet derived growth factor C |
| chr2_-_161350305 | 5.12 |
ENST00000348849.3 |
RBMS1 |
RNA binding motif, single stranded interacting protein 1 |
| chr2_-_1748214 | 5.09 |
ENST00000433670.1 ENST00000425171.1 ENST00000252804.4 |
PXDN |
peroxidasin homolog (Drosophila) |
| chr3_-_120170052 | 4.78 |
ENST00000295633.3 |
FSTL1 |
follistatin-like 1 |
| chr12_+_66217911 | 4.47 |
ENST00000403681.2 |
HMGA2 |
high mobility group AT-hook 2 |
| chr2_+_36582857 | 4.18 |
ENST00000280527.2 |
CRIM1 |
cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| chr6_-_169654139 | 4.01 |
ENST00000366787.3 |
THBS2 |
thrombospondin 2 |
| chr9_+_115913222 | 3.99 |
ENST00000259392.3 |
SLC31A2 |
solute carrier family 31 (copper transporter), member 2 |
| chr3_-_134093395 | 3.92 |
ENST00000249883.5 |
AMOTL2 |
angiomotin like 2 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 8.5 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.2 | 6.0 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.1 | 5.1 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 1.5 | 4.5 | GO:0035978 | mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685) |
| 0.0 | 4.1 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.4 | 3.8 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 3.5 | GO:0061462 | protein localization to lysosome(GO:0061462) |
| 0.2 | 3.4 | GO:1902284 | axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284) |
| 0.0 | 3.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 11.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 7.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 5.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 5.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.4 | 4.5 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 3.8 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 3.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.4 | 3.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 15.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 6.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 4.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 4.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 6.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.2 | 6.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 6.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 5.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 4.6 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.1 | 4.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 4.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 3.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 3.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 5.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 5.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.3 | 5.2 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 1.0 | 5.1 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.2 | 4.8 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 1.5 | 4.5 | GO:0035501 | MH1 domain binding(GO:0035501) |
| 0.2 | 3.9 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.6 | 3.8 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.5 | 3.8 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |