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ENCODE cell lines, expression (Ernst 2011)
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Results for DLX4_HOXD8
Z-value: 1.32
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Transcription factors associated with DLX4_HOXD8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX4 | hg19_v2_chr17_+_48046538_48046575 | 0.88 | 6.0e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX4_HOXD8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_7745303 | 8.33 |
ENST00000429820.1 ENST00000379587.4 |
ITIH2 |
inter-alpha-trypsin inhibitor heavy chain 2 |
| chr17_-_64225508 | 8.32 |
ENST00000205948.6 |
APOH |
apolipoprotein H (beta-2-glycoprotein I) |
| chr4_+_69962185 | 6.11 |
ENST00000305231.7 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr4_+_69962212 | 5.98 |
ENST00000508661.1 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr17_-_64216748 | 5.70 |
ENST00000585162.1 |
APOH |
apolipoprotein H (beta-2-glycoprotein I) |
| chr4_+_69681710 | 5.41 |
ENST00000265403.7 ENST00000458688.2 |
UGT2B10 |
UDP glucuronosyltransferase 2 family, polypeptide B10 |
| chr4_+_74275057 | 5.05 |
ENST00000511370.1 |
ALB |
albumin |
| chr10_+_7745232 | 4.81 |
ENST00000358415.4 |
ITIH2 |
inter-alpha-trypsin inhibitor heavy chain 2 |
| chr4_-_69817481 | 3.56 |
ENST00000251566.4 |
UGT2A3 |
UDP glucuronosyltransferase 2 family, polypeptide A3 |
| chr10_+_5005445 | 3.30 |
ENST00000380872.4 |
AKR1C1 |
aldo-keto reductase family 1, member C1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 10.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 7.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 4.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 3.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 2.8 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 2.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 2.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 2.0 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 3.6 | 18.0 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 15.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.2 | 8.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 7.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.7 | 6.8 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.3 | 5.1 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.9 | 3.5 | GO:0047086 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.0 | 3.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.8 | 3.0 | GO:0019862 | IgA binding(GO:0019862) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.9 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 1.3 | 8.9 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.1 | 8.4 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.4 | 8.1 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.4 | 8.1 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 1.7 | 5.1 | GO:0052331 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.0 | 4.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 4.7 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 4.2 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 1.3 | 4.0 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 21.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.5 | 6.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 4.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 3.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 3.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.7 | 2.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.3 | 2.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 2.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 2.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.8 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |