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ENCODE cell lines, expression (Ernst 2011)
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Results for E2F6
Z-value: 1.32
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11606275_11606289 | -0.19 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_95653427 | 4.50 |
ENST00000454170.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr10_-_126849588 | 4.25 |
ENST00000411419.2 |
CTBP2 |
C-terminal binding protein 2 |
| chr8_+_95653373 | 4.08 |
ENST00000358397.5 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr6_+_83073952 | 3.73 |
ENST00000543496.1 |
TPBG |
trophoblast glycoprotein |
| chr10_-_126849068 | 3.67 |
ENST00000494626.2 ENST00000337195.5 |
CTBP2 |
C-terminal binding protein 2 |
| chr8_+_95653302 | 2.81 |
ENST00000423620.2 ENST00000433389.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr12_+_6309517 | 2.64 |
ENST00000382519.4 ENST00000009180.4 |
CD9 |
CD9 molecule |
| chr3_-_98620500 | 2.54 |
ENST00000326840.6 |
DCBLD2 |
discoidin, CUB and LCCL domain containing 2 |
| chr2_-_235405679 | 2.38 |
ENST00000390645.2 |
ARL4C |
ADP-ribosylation factor-like 4C |
| chr7_+_116165038 | 2.26 |
ENST00000393470.1 |
CAV1 |
caveolin 1, caveolae protein, 22kDa |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.8 | 7.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.7 | 5.2 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.2 | 4.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 4.4 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.6 | 4.3 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 3.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.3 | 3.3 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.2 | 3.2 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.2 | 3.1 | GO:0051639 | actin filament network formation(GO:0051639) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 7.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 4.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 4.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 3.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.7 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 3.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.6 | 8.0 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 7.6 | GO:0009986 | cell surface(GO:0009986) |
| 0.4 | 6.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 5.6 | GO:0042641 | actomyosin(GO:0042641) |
| 0.2 | 5.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.4 | 4.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 3.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.4 | 2.6 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 2.5 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.1 | 8.0 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 7.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 5.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 4.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 4.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 4.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.8 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.3 | 3.7 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.2 | 3.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 5.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 4.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 4.1 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 4.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 4.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 3.9 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.1 | 3.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |