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ENCODE cell lines, expression (Ernst 2011)
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Results for E2F7_E2F1
Z-value: 3.31
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.60 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_47630108 | 6.79 |
ENST00000233146.2 ENST00000454849.1 ENST00000543555.1 |
MSH2 |
mutS homolog 2 |
| chr2_+_47630255 | 6.70 |
ENST00000406134.1 |
MSH2 |
mutS homolog 2 |
| chr7_-_148581251 | 6.24 |
ENST00000478654.1 ENST00000460911.1 ENST00000350995.2 |
EZH2 |
enhancer of zeste homolog 2 (Drosophila) |
| chr5_+_126112794 | 5.87 |
ENST00000261366.5 ENST00000395354.1 |
LMNB1 |
lamin B1 |
| chr22_+_23237555 | 5.67 |
ENST00000390321.2 |
IGLC1 |
immunoglobulin lambda constant 1 (Mcg marker) |
| chr18_+_29077990 | 5.57 |
ENST00000261590.8 |
DSG2 |
desmoglein 2 |
| chr8_+_48873479 | 5.53 |
ENST00000262105.2 |
MCM4 |
minichromosome maintenance complex component 4 |
| chr7_-_99698338 | 5.51 |
ENST00000354230.3 ENST00000425308.1 |
MCM7 |
minichromosome maintenance complex component 7 |
| chr8_+_48873453 | 5.49 |
ENST00000523944.1 |
MCM4 |
minichromosome maintenance complex component 4 |
| chr7_-_148581360 | 5.39 |
ENST00000320356.2 ENST00000541220.1 ENST00000483967.1 ENST00000536783.1 |
EZH2 |
enhancer of zeste homolog 2 (Drosophila) |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 29.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 13.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 9.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 9.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 9.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 8.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 8.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 6.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 33.5 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 24.0 | GO:0005730 | nucleolus(GO:0005730) |
| 1.0 | 14.7 | GO:0045120 | pronucleus(GO:0045120) |
| 4.7 | 14.0 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 0.1 | 13.3 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 13.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.2 | 12.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 10.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 1.4 | 9.8 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 9.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 24.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.4 | 23.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 2.1 | 16.7 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 2.7 | 13.5 | GO:0006311 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 3.9 | 11.6 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.1 | 10.4 | GO:0051225 | spindle assembly(GO:0051225) |
| 2.0 | 9.8 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 1.9 | 9.4 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.1 | 9.3 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 1.6 | 8.0 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 40.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.5 | 33.6 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 1.0 | 19.1 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.4 | 18.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 18.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 12.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.6 | 11.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 10.2 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 9.0 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.3 | 7.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 25.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 22.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 2.1 | 19.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 16.0 | GO:0003677 | DNA binding(GO:0003677) |
| 4.7 | 14.0 | GO:0000406 | heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.7 | 11.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 11.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 1.1 | 11.2 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 1.3 | 9.2 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |