ISMARA results: EBF1

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ENCODE cell lines, expression (Ernst 2011)

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Results for EBF1

Z-value: 2.13

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Transcription factors associated with EBF1

Gene Symbol	Gene ID	Gene Info
EBF1 Ensembl NCBI GeneCards UniProt	ENSG00000164330.12	EBF1

Activity profile of EBF1 motif

Sorted Z-values of EBF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF1

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Promoter	Score	Transcript	Gene	Gene Info
chr22_+_23229960	6.91	ENST00000526893.1 ENST00000532223.2 ENST00000531372.1	IGLL5	immunoglobulin lambda-like polypeptide 5
chr22_+_23101182	4.52	ENST00000390312.2	IGLV2-14	immunoglobulin lambda variable 2-14
chr5_-_149792295	4.31	ENST00000518797.1 ENST00000524315.1 ENST00000009530.7 ENST00000377795.3	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr22_+_23134974	3.99	ENST00000390314.2	IGLV2-11	immunoglobulin lambda variable 2-11
chr6_-_167369612	3.84	ENST00000507747.1	RP11-514O12.4	RP11-514O12.4
chr22_+_23165153	3.68	ENST00000390317.2	IGLV2-8	immunoglobulin lambda variable 2-8
chr14_+_105953204	3.64	ENST00000409393.2	CRIP1	cysteine-rich protein 1 (intestinal)
chr14_+_105953246	3.48	ENST00000392531.3	CRIP1	cysteine-rich protein 1 (intestinal)
chr22_+_23241661	3.46	ENST00000390322.2	IGLJ2	immunoglobulin lambda joining 2
chr11_+_121447469	3.45	ENST00000532694.1 ENST00000534286.1	SORL1	sortilin-related receptor, L(DLR class) A repeats containing

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	14.3	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.6	13.6	GO:0015929	hexosaminidase activity(GO:0015929)
3.2	9.6	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.1	9.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	8.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.3	7.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.2	5.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	5.2	GO:0008013	beta-catenin binding(GO:0008013)
0.1	5.0	GO:0042169	SH2 domain binding(GO:0042169)
0.3	4.9	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)

Showing 1 to 10 of 234 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	12.9	GO:1904715	negative regulation of chaperone-mediated autophagy(GO:1904715)
2.4	9.6	GO:0002086	maltose metabolic process(GO:0000023) diaphragm contraction(GO:0002086)
0.9	9.0	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.6	8.4	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.3	8.4	GO:0006884	cell volume homeostasis(GO:0006884)
1.1	7.7	GO:0018158	protein oxidation(GO:0018158)
0.4	7.3	GO:0042340	keratan sulfate catabolic process(GO:0042340)
1.0	6.1	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
1.5	6.0	GO:0043323	regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.1	5.9	GO:0046324	regulation of glucose import(GO:0046324)

Showing 1 to 10 of 347 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	17.4	GO:0042571	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.5	11.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	9.2	GO:0009897	external side of plasma membrane(GO:0009897)
1.0	7.8	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.4	6.7	GO:0042627	chylomicron(GO:0042627)
0.9	6.3	GO:0019815	B cell receptor complex(GO:0019815)
0.3	6.0	GO:0001891	phagocytic cup(GO:0001891)
0.5	5.6	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	5.1	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.6	4.9	GO:0071745	IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)

Showing 1 to 10 of 185 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.9	PID BCR 5PATHWAY	BCR signaling pathway
0.2	10.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	9.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	6.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	6.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	5.5	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	4.4	PID INSULIN PATHWAY	Insulin Pathway
0.0	2.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	2.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	2.3	PID IL12 2PATHWAY	IL12-mediated signaling events

Showing 1 to 10 of 63 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	43.6	GO:0006958	complement activation, classical pathway(GO:0006958)
2.0	9.8	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
2.4	9.5	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.2	8.6	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.1	8.4	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.3	6.9	GO:0000185	activation of MAPKKK activity(GO:0000185)
1.4	5.6	GO:0033277	abortive mitotic cell cycle(GO:0033277)
1.0	5.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.2	4.8	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	4.8	GO:0031295	T cell costimulation(GO:0031295)

Showing 1 to 10 of 538 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	18.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	8.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	7.9	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2	5.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	5.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.3	5.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	5.2	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.4	4.8	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	4.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	4.3	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement

Showing 1 to 10 of 71 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	15.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	11.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	6.4	PID BMP PATHWAY	BMP receptor signaling
0.1	4.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	4.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	4.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	4.5	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	4.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	3.9	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4	9.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	8.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	8.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3	6.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	6.1	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.4	5.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	4.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	4.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	4.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Showing 1 to 10 of 98 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.9	GO:0043202	lysosomal lumen(GO:0043202)
1.9	13.1	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.0	12.7	GO:0005938	cell cortex(GO:0005938)
0.1	11.8	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1	9.4	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	8.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	7.7	GO:0005901	caveola(GO:0005901)
0.7	6.9	GO:0097413	Lewy body(GO:0097413)
0.8	6.7	GO:0097208	alveolar lamellar body(GO:0097208)
0.1	6.2	GO:0016235	aggresome(GO:0016235)

Showing 1 to 10 of 130 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	28.7	GO:0003823	antigen binding(GO:0003823)
0.4	22.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.4	9.5	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.5	9.1	GO:0003680	AT DNA binding(GO:0003680)
1.0	7.6	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.4	6.9	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.2	6.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.2	5.6	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	5.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.6	4.4	GO:0005353	fructose transmembrane transporter activity(GO:0005353)

Showing 1 to 10 of 360 entries

Results for EBF1

Z-value: 2.13

Motif logo

Transcription factors associated with EBF1

Activity profile of EBF1 motif

Sorted Z-values of EBF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category: