ISMARA results: ELF2_GABPA

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ENCODE cell lines, expression (Ernst 2011)

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Results for ELF2_GABPA_ELF5

Z-value: 3.07

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Transcription factors associated with ELF2_GABPA_ELF5

Gene Symbol	Gene ID	Gene Info
ELF2 Ensembl NCBI GeneCards UniProt	ENSG00000109381.15	ELF2
GABPA Ensembl NCBI GeneCards UniProt	ENSG00000154727.6	GABPA
ELF5 Ensembl NCBI GeneCards UniProt	ENSG00000135374.5	ELF5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GABPA	hg19_v2_chr21_+_27107672_27107698	0.56	2.4e-02	Click!
ELF5	hg19_v2_chr11_-_34533257_34533346	0.41	1.2e-01	Click!
ELF2	hg19_v2_chr4_-_140005341_140005411, hg19_v2_chr4_-_140098339_140098392	0.08	7.7e-01	Click!

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Promoter	Score	Transcript	Gene	Gene Info
chr10_-_98031310	7.56	ENST00000427367.2 ENST00000413476.2	BLNK	B-cell linker
chr15_+_91260552	7.25	ENST00000355112.3 ENST00000560509.1	BLM	Bloom syndrome, RecQ helicase-like
chr10_-_98031265	6.63	ENST00000224337.5 ENST00000371176.2	BLNK	B-cell linker
chr7_-_2281802	6.46	ENST00000242257.8 ENST00000440306.2	FTSJ2	FtsJ RNA methyltransferase homolog 2 (E. coli)
chr6_+_33048222	6.13	ENST00000428835.1	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr11_-_57194418	5.73	ENST00000395123.2 ENST00000530005.1 ENST00000532278.1	SLC43A3	solute carrier family 43, member 3
chr6_-_33048483	5.61	ENST00000419277.1	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1
chr11_-_58345569	5.54	ENST00000528954.1 ENST00000528489.1	LPXN	leupaxin
chr1_-_156698591	5.53	ENST00000368219.1	ISG20L2	interferon stimulated exonuclease gene 20kDa-like 2
chr14_+_75988851	5.21	ENST00000555504.1	BATF	basic leucine zipper transcription factor, ATF-like

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	61.2	GO:0005634	nucleus(GO:0005634)
0.2	60.2	GO:0016607	nuclear speck(GO:0016607)
0.1	58.7	GO:0005739	mitochondrion(GO:0005739)
0.1	40.0	GO:0031965	nuclear membrane(GO:0031965)
0.1	29.5	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.2	24.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.3	24.1	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.3	18.1	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4	16.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	16.2	GO:0005741	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)

Showing 1 to 10 of 426 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	122.2	GO:0003677	DNA binding(GO:0003677)
0.1	35.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	21.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	18.7	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.5	15.7	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175)
0.4	15.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.5	14.0	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.9	13.9	GO:0031996	thioesterase binding(GO:0031996)
0.8	13.7	GO:0001054	RNA polymerase I activity(GO:0001054)
0.2	13.4	GO:0003954	NADH dehydrogenase activity(GO:0003954)

Showing 1 to 10 of 696 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	46.9	PID BCR 5PATHWAY	BCR signaling pathway
0.6	34.2	PID ATM PATHWAY	ATM pathway
0.3	25.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	24.1	PID ATR PATHWAY	ATR signaling pathway
0.4	23.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1	15.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.4	14.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.6	14.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	14.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	14.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 105 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	29.5	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.4	24.4	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.2	20.9	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.5	20.2	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.3	18.8	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
2.3	18.3	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.6	17.9	GO:0006270	DNA replication initiation(GO:0006270)
0.1	13.5	GO:0090305	nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.3	12.9	GO:0032729	positive regulation of interferon-gamma production(GO:0032729)
0.1	11.9	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)

Showing 1 to 10 of 1,147 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	39.3	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
1.2	32.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	28.9	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.8	28.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.3	27.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.4	27.4	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.3	27.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	24.4	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.3	22.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.6	19.4	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair

Showing 1 to 10 of 176 entries

Results for ELF2_GABPA_ELF5

Z-value: 3.07

Motif logo

Transcription factors associated with ELF2_GABPA_ELF5

Activity-expression correlation:

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category: