ISMARA results: ELK4_ETV5_ELK1_ELK3

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ENCODE cell lines, expression (Ernst 2011)

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Results for ELK4_ETV5_ELK1_ELK3_ELF4

Z-value: 2.35

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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4

Gene Symbol	Gene ID	Gene Info
ELK4 Ensembl NCBI GeneCards UniProt	ENSG00000158711.9	ELK4
ETV5 Ensembl NCBI GeneCards UniProt	ENSG00000244405.3	ETV5
ELK1 Ensembl NCBI GeneCards UniProt	ENSG00000126767.13	ELK1
ELK3 Ensembl NCBI GeneCards UniProt	ENSG00000111145.3	ELK3
ELF4 Ensembl NCBI GeneCards UniProt	ENSG00000102034.12	ELF4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ELK3	hg19_v2_chr12_+_96588143_96588185	-0.76	6.8e-04	Click!
ELK1	hg19_v2_chrX_-_47509887_47509990	0.72	1.6e-03	Click!
ELF4	hg19_v2_chrX_-_129244655_129244697, hg19_v2_chrX_-_129244454_129244488	0.51	4.4e-02	Click!
ELK4	hg19_v2_chr1_-_205601064_205601090	0.42	1.1e-01	Click!
ETV5	hg19_v2_chr3_-_185826855_185826911	-0.24	3.6e-01	Click!

Activity profile of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Sorted Z-values of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4

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Promoter	Score	Transcript	Gene	Gene Info
chrX_+_30233668	8.95	ENST00000378988.4	MAGEB2	melanoma antigen family B, 2
chr1_-_52870059	5.24	ENST00000371566.1	ORC1	origin recognition complex, subunit 1
chr7_-_128694927	4.78	ENST00000471166.1 ENST00000265388.5	TNPO3	transportin 3
chr15_+_74833518	4.61	ENST00000346246.5	ARID3B	AT rich interactive domain 3B (BRIGHT-like)
chr1_-_236767779	4.61	ENST00000366579.1 ENST00000366582.3 ENST00000366581.2	HEATR1	HEAT repeat containing 1
chr15_+_91260552	4.51	ENST00000355112.3 ENST00000560509.1	BLM	Bloom syndrome, RecQ helicase-like
chr1_-_52870104	4.41	ENST00000371568.3	ORC1	origin recognition complex, subunit 1
chr21_-_33984865	4.39	ENST00000458138.1	C21orf59	chromosome 21 open reading frame 59
chr17_-_56595196	4.36	ENST00000579921.1 ENST00000579925.1 ENST00000323456.5	MTMR4	myotubularin related protein 4
chr5_+_102455968	4.26	ENST00000358359.3	PPIP5K2	diphosphoinositol pentakisphosphate kinase 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	37.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.9	35.0	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.6	24.9	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.6	23.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.2	19.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	16.7	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2	16.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	15.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.4	14.6	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.5	13.9	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway

Showing 1 to 10 of 170 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	72.6	GO:0005730	nucleolus(GO:0005730)
0.0	39.4	GO:0005654	nucleoplasm(GO:0005654)
0.1	33.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.5	25.6	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2	23.1	GO:0005681	spliceosomal complex(GO:0005681)
0.2	17.9	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.6	16.0	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.2	15.9	GO:0000793	condensed chromosome(GO:0000793)
0.4	14.4	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.8	14.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)

Showing 1 to 10 of 389 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	115.9	GO:0003677	DNA binding(GO:0003677)
0.0	36.0	GO:0003676	nucleic acid binding(GO:0003676)
0.1	26.4	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	21.3	GO:0042393	histone binding(GO:0042393)
0.3	20.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.7	19.9	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.3	17.9	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.5	17.8	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.6	16.7	GO:0030515	snoRNA binding(GO:0030515)
0.8	14.1	GO:0001054	RNA polymerase I activity(GO:0001054)

Showing 1 to 10 of 618 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	34.4	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.7	30.8	GO:0006270	DNA replication initiation(GO:0006270)
0.6	25.0	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.5	20.4	GO:0051031	tRNA transport(GO:0051031)
0.3	18.8	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.1	18.3	GO:0008380	RNA splicing(GO:0008380)
0.1	14.4	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3	12.9	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.7	11.8	GO:0006265	DNA topological change(GO:0006265)
0.2	10.8	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)

Showing 1 to 10 of 1,049 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	29.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	18.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	15.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	13.8	PID AURORA B PATHWAY	Aurora B signaling
0.2	12.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1	11.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	9.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	9.6	PID ATM PATHWAY	ATM pathway
0.4	9.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	9.1	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 92 entries

Results for ELK4_ETV5_ELK1_ELK3_ELF4

Z-value: 2.35

Motif logo

Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4

Activity-expression correlation:

Activity profile of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Sorted Z-values of ELK4_ETV5_ELK1_ELK3_ELF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category: