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ENCODE cell lines, expression (Ernst 2011)
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Results for ERG
Z-value: 1.32
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Transcription factors associated with ERG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg19_v2_chr21_-_39870339_39870443, hg19_v2_chr21_-_40033618_40033712 | 0.86 | 1.9e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_6233828 | 3.53 |
ENST00000572068.1 ENST00000261405.5 |
VWF |
von Willebrand factor |
| chr4_+_90816033 | 3.25 |
ENST00000264790.2 ENST00000394981.1 |
MMRN1 |
multimerin 1 |
| chr9_-_130616915 | 2.66 |
ENST00000344849.3 |
ENG |
endoglin |
| chr17_-_62097904 | 2.29 |
ENST00000583366.1 |
ICAM2 |
intercellular adhesion molecule 2 |
| chr17_+_32582293 | 2.22 |
ENST00000580907.1 ENST00000225831.4 |
CCL2 |
chemokine (C-C motif) ligand 2 |
| chr1_-_79472365 | 2.21 |
ENST00000370742.3 |
ELTD1 |
EGF, latrophilin and seven transmembrane domain containing 1 |
| chr17_-_62097927 | 2.20 |
ENST00000578313.1 ENST00000584084.1 ENST00000579788.1 ENST00000579687.1 ENST00000578379.1 ENST00000578892.1 ENST00000412356.1 ENST00000418105.1 |
ICAM2 |
intercellular adhesion molecule 2 |
| chr17_-_62084241 | 2.07 |
ENST00000449662.2 |
ICAM2 |
intercellular adhesion molecule 2 |
| chr9_-_130617029 | 2.03 |
ENST00000373203.4 |
ENG |
endoglin |
| chr1_+_186798073 | 1.97 |
ENST00000367466.3 ENST00000442353.2 |
PLA2G4A |
phospholipase A2, group IVA (cytosolic, calcium-dependent) |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 6.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.6 | 4.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.4 | 4.7 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 4.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 4.3 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.0 | 3.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 3.1 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 3.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 2.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 4.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 3.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 3.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.9 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 2.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 2.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.4 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.3 | 5.9 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.6 | 4.7 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.1 | 4.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 4.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 4.3 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 4.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 3.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 3.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 6.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 4.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 3.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.3 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 3.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.1 | 5.3 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.2 | 4.6 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.0 | 3.8 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.1 | 3.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 1.0 | 3.1 | GO:2000439 | positive regulation of monocyte extravasation(GO:2000439) |
| 0.0 | 3.0 | GO:0001570 | vasculogenesis(GO:0001570) |
| 0.0 | 3.0 | GO:0045995 | regulation of embryonic development(GO:0045995) |
| 0.2 | 2.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.8 | 2.3 | GO:0072683 | T cell extravasation(GO:0072683) |