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ENCODE cell lines, expression (Ernst 2011)
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Results for ESR1
Z-value: 1.12
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Transcription factors associated with ESR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR1 | hg19_v2_chr6_+_152130240_152130274 | 0.50 | 4.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESR1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106054659 | 2.80 |
ENST00000390539.2 |
IGHA2 |
immunoglobulin heavy constant alpha 2 (A2m marker) |
| chr22_+_23165153 | 2.58 |
ENST00000390317.2 |
IGLV2-8 |
immunoglobulin lambda variable 2-8 |
| chr22_+_23248512 | 2.34 |
ENST00000390325.2 |
IGLC3 |
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
| chr22_+_23077065 | 2.19 |
ENST00000390310.2 |
IGLV2-18 |
immunoglobulin lambda variable 2-18 |
| chr14_-_106209368 | 1.99 |
ENST00000390548.2 ENST00000390549.2 ENST00000390542.2 |
IGHG1 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
| chr22_+_23247030 | 1.98 |
ENST00000390324.2 |
IGLJ3 |
immunoglobulin lambda joining 3 |
| chr15_+_89182178 | 1.89 |
ENST00000559876.1 |
ISG20 |
interferon stimulated exonuclease gene 20kDa |
| chr22_+_22930626 | 1.86 |
ENST00000390302.2 |
IGLV2-33 |
immunoglobulin lambda variable 2-33 (non-functional) |
| chr10_+_115438920 | 1.76 |
ENST00000429617.1 ENST00000369331.4 |
CASP7 |
caspase 7, apoptosis-related cysteine peptidase |
| chr15_+_89181974 | 1.76 |
ENST00000306072.5 |
ISG20 |
interferon stimulated exonuclease gene 20kDa |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 7.5 | GO:0003823 | antigen binding(GO:0003823) |
| 1.8 | 5.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 2.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 1.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 1.2 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.0 | 1.2 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 1.1 | GO:0019863 | IgE binding(GO:0019863) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 5.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 3.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 2.8 | GO:0071748 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.0 | 2.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 1.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 1.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 1.4 | GO:0034448 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 1.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 1.1 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.3 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 1.1 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 1.1 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 1.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 3.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.3 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.8 | 5.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 5.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 3.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 2.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.4 | 2.1 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.1 | 2.1 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.2 | 2.0 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.2 | 1.8 | GO:0072733 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.1 | 1.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |