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ENCODE cell lines, expression (Ernst 2011)
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Results for ESRRA_ESR2
Z-value: 3.21
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | 0.62 | 9.9e-03 | Click! |
| ESRRA | hg19_v2_chr11_+_64073699_64073918, hg19_v2_chr11_+_64073022_64073056 | 0.35 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_167369612 | 11.00 |
ENST00000507747.1 |
RP11-514O12.4 |
RP11-514O12.4 |
| chr14_-_106174960 | 9.93 |
ENST00000390547.2 |
IGHA1 |
immunoglobulin heavy constant alpha 1 |
| chr22_+_23248512 | 7.12 |
ENST00000390325.2 |
IGLC3 |
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
| chr22_+_23243156 | 6.97 |
ENST00000390323.2 |
IGLC2 |
immunoglobulin lambda constant 2 (Kern-Oz- marker) |
| chr22_+_23237555 | 6.94 |
ENST00000390321.2 |
IGLC1 |
immunoglobulin lambda constant 1 (Mcg marker) |
| chr9_-_116840728 | 6.88 |
ENST00000265132.3 |
AMBP |
alpha-1-microglobulin/bikunin precursor |
| chr2_+_228678550 | 6.28 |
ENST00000409189.3 ENST00000358813.4 |
CCL20 |
chemokine (C-C motif) ligand 20 |
| chr14_-_106054659 | 6.17 |
ENST00000390539.2 |
IGHA2 |
immunoglobulin heavy constant alpha 2 (A2m marker) |
| chr22_+_23241661 | 6.05 |
ENST00000390322.2 |
IGLJ2 |
immunoglobulin lambda joining 2 |
| chr3_+_133465228 | 5.87 |
ENST00000482271.1 ENST00000264998.3 |
TF |
transferrin |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 50.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 23.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 21.5 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.7 | 16.6 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.3 | 15.1 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 2.9 | 11.7 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 0.9 | 11.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 10.5 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 10.1 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 3.3 | 10.0 | GO:1903413 | cellular response to bile acid(GO:1903413) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 23.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 15.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 14.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.6 | 14.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 12.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 11.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 10.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 9.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 9.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 66.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 31.3 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
| 0.2 | 30.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 24.0 | GO:0003677 | DNA binding(GO:0003677) |
| 0.2 | 17.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 15.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 15.5 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 1.8 | 14.3 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.5 | 13.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 2.9 | 11.7 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 49.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 45.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 27.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.0 | 21.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.7 | 21.6 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 5.5 | 16.4 | GO:0071749 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.2 | 13.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.8 | 13.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 13.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.6 | 11.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 27.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.9 | 20.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.2 | 19.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 18.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 16.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.8 | 16.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 13.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 13.2 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.1 | 12.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 10.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |