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ENCODE cell lines, expression (Ernst 2011)
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Results for FLI1
Z-value: 1.60
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Transcription factors associated with FLI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FLI1 | hg19_v2_chr11_+_128563948_128564003, hg19_v2_chr11_+_128634589_128634685, hg19_v2_chr11_+_128563652_128563689, hg19_v2_chr11_+_128562372_128562397 | 0.57 | 2.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FLI1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_102631844 | 2.81 |
ENST00000372634.1 ENST00000299872.7 |
NGFRAP1 |
nerve growth factor receptor (TNFRSF16) associated protein 1 |
| chr7_+_93551011 | 2.76 |
ENST00000248564.5 |
GNG11 |
guanine nucleotide binding protein (G protein), gamma 11 |
| chr4_+_90816033 | 2.65 |
ENST00000264790.2 ENST00000394981.1 |
MMRN1 |
multimerin 1 |
| chrX_+_114827818 | 2.61 |
ENST00000420625.2 |
PLS3 |
plastin 3 |
| chr7_+_100770328 | 2.61 |
ENST00000223095.4 ENST00000445463.2 |
SERPINE1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| chr3_-_158390282 | 2.55 |
ENST00000264265.3 |
LXN |
latexin |
| chrY_+_2709906 | 2.37 |
ENST00000430575.1 |
RPS4Y1 |
ribosomal protein S4, Y-linked 1 |
| chr8_+_74903580 | 2.31 |
ENST00000284818.2 ENST00000518893.1 |
LY96 |
lymphocyte antigen 96 |
| chr1_+_84609944 | 2.28 |
ENST00000370685.3 |
PRKACB |
protein kinase, cAMP-dependent, catalytic, beta |
| chr15_+_71185148 | 2.24 |
ENST00000443425.2 ENST00000560755.1 |
LRRC49 |
leucine rich repeat containing 49 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.2 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 7.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 7.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 6.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 5.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 5.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.6 | 3.9 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 3.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 3.7 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 3.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.9 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.0 | 4.9 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 1.6 | 4.8 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.1 | 4.3 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 1.3 | 3.9 | GO:2000521 | negative regulation of immunological synapse formation(GO:2000521) |
| 0.1 | 3.9 | GO:0006144 | purine nucleobase metabolic process(GO:0006144) |
| 0.2 | 3.5 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.7 | 3.4 | GO:0045626 | negative regulation of T-helper 1 cell differentiation(GO:0045626) |
| 0.2 | 2.8 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 2.8 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 5.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 5.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 5.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 3.9 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.5 | 3.9 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 3.1 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 3.1 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 2.9 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 4.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 4.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 3.6 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 3.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 3.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 2.8 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 2.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 2.4 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 6.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 6.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 4.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 3.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 3.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 2.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |