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ENCODE cell lines, expression (Ernst 2011)
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Results for FOSL1
Z-value: 2.68
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667997_65668044 | 0.90 | 2.8e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21452804 | 20.52 |
ENST00000269217.6 |
LAMA3 |
laminin, alpha 3 |
| chr18_+_21452964 | 18.15 |
ENST00000587184.1 |
LAMA3 |
laminin, alpha 3 |
| chr1_-_95007193 | 15.85 |
ENST00000370207.4 ENST00000334047.7 |
F3 |
coagulation factor III (thromboplastin, tissue factor) |
| chr1_-_151965048 | 15.01 |
ENST00000368809.1 |
S100A10 |
S100 calcium binding protein A10 |
| chr1_+_223889285 | 14.35 |
ENST00000433674.2 |
CAPN2 |
calpain 2, (m/II) large subunit |
| chr3_-_151034734 | 12.76 |
ENST00000260843.4 |
GPR87 |
G protein-coupled receptor 87 |
| chr17_-_39743139 | 12.68 |
ENST00000167586.6 |
KRT14 |
keratin 14 |
| chr1_+_183155373 | 12.41 |
ENST00000493293.1 ENST00000264144.4 |
LAMC2 |
laminin, gamma 2 |
| chr12_+_13349650 | 12.15 |
ENST00000256951.5 ENST00000431267.2 ENST00000542474.1 ENST00000544053.1 |
EMP1 |
epithelial membrane protein 1 |
| chr10_+_17270214 | 12.11 |
ENST00000544301.1 |
VIM |
vimentin |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 64.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.4 | 36.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 25.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 22.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 22.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 21.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 17.5 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 12.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 10.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 10.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 75.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 22.9 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 1.1 | 21.6 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 1.0 | 18.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 5.3 | 15.9 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.8 | 15.0 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.9 | 12.2 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.7 | 12.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.6 | 11.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.2 | 11.1 | GO:0030574 | collagen catabolic process(GO:0030574) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 45.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 42.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.7 | 38.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.0 | 23.3 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.8 | 15.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 4.7 | 14.1 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.1 | 12.5 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 1.5 | 10.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.5 | 9.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 7.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 63.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 15.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.5 | 13.3 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.5 | 12.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.6 | 10.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.7 | 10.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 8.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 8.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 7.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 7.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 75.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 32.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.1 | 24.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.5 | 20.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.5 | 14.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.9 | 13.3 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 13.0 | GO:0002020 | protease binding(GO:0002020) |
| 0.6 | 11.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 2.6 | 10.3 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.3 | 10.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |