ISMARA results: FOXK1_FOXP2_FOXB1

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ENCODE cell lines, expression (Ernst 2011)

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Results for FOXK1_FOXP2_FOXB1_FOXP3

Z-value: 1.71

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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3

Gene Symbol	Gene ID	Gene Info
FOXK1 Ensembl NCBI GeneCards UniProt	ENSG00000164916.9	FOXK1
FOXP2 Ensembl NCBI GeneCards UniProt	ENSG00000128573.18	FOXP2
FOXB1 Ensembl NCBI GeneCards UniProt	ENSG00000171956.5	FOXB1
FOXP3 Ensembl NCBI GeneCards UniProt	ENSG00000049768.10	FOXP3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXP3	hg19_v2_chrX_-_49121165_49121288	-0.49	5.1e-02	Click!
FOXK1	hg19_v2_chr7_+_4721885_4721945	0.39	1.3e-01	Click!
FOXB1	hg19_v2_chr15_+_60296421_60296464	-0.38	1.5e-01	Click!

Activity profile of FOXK1_FOXP2_FOXB1_FOXP3 motif

Sorted Z-values of FOXK1_FOXP2_FOXB1_FOXP3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3

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Promoter	Score	Transcript	Gene	Gene Info
chr7_+_134551583	8.78	ENST00000435928.1	CALD1	caldesmon 1
chr10_-_101841588	8.56	ENST00000370418.3	CPN1	carboxypeptidase N, polypeptide 1
chr5_-_42811986	7.86	ENST00000511224.1 ENST00000507920.1 ENST00000510965.1	SEPP1	selenoprotein P, plasma, 1
chr5_-_42812143	7.70	ENST00000514985.1	SEPP1	selenoprotein P, plasma, 1
chr12_-_9268707	7.34	ENST00000318602.7	A2M	alpha-2-macroglobulin
chr1_-_161193349	6.71	ENST00000469730.2 ENST00000463273.1 ENST00000464492.1 ENST00000367990.3 ENST00000470459.2 ENST00000468465.1 ENST00000463812.1	APOA2	apolipoprotein A-II
chr17_-_64225508	6.37	ENST00000205948.6	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr10_-_52645379	6.07	ENST00000395489.2	A1CF	APOBEC1 complementation factor
chr7_+_134464414	5.90	ENST00000361901.2	CALD1	caldesmon 1
chr10_-_52645416	5.83	ENST00000374001.2 ENST00000373997.3 ENST00000373995.3 ENST00000282641.2 ENST00000395495.1 ENST00000414883.1	A1CF	APOBEC1 complementation factor

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	16.3	GO:0006936	muscle contraction(GO:0006936)
0.2	14.4	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
2.0	11.9	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	11.5	GO:0021987	cerebral cortex development(GO:0021987)
1.0	10.9	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
1.3	10.5	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
2.0	9.8	GO:0030070	insulin processing(GO:0030070)
1.1	9.8	GO:1903027	regulation of opsonization(GO:1903027)
1.6	9.4	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.6	7.8	GO:0001867	complement activation, lectin pathway(GO:0001867)

Showing 1 to 10 of 436 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	11.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	10.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	9.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	8.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	7.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	6.8	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	5.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	5.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 52 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	30.8	GO:0030478	actin cap(GO:0030478)
0.8	18.8	GO:0042627	chylomicron(GO:0042627)
0.1	17.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	14.5	GO:0031674	I band(GO:0031674)
0.1	12.2	GO:0031225	anchored component of membrane(GO:0031225)
4.0	11.9	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1	11.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
1.6	9.4	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
0.6	7.7	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	7.7	GO:0044215	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)

Showing 1 to 10 of 176 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	35.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.6	23.8	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.6	15.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.4	11.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	9.2	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.4	8.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	7.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	5.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	4.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	4.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	27.7	GO:0005523	tropomyosin binding(GO:0005523)
0.2	19.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.7	13.9	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.7	12.6	GO:0045295	gamma-catenin binding(GO:0045295)
0.8	12.3	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	11.0	GO:0003725	double-stranded RNA binding(GO:0003725)
2.2	10.9	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	10.9	GO:0005178	integrin binding(GO:0005178)
0.1	10.1	GO:0035257	nuclear hormone receptor binding(GO:0035257)
0.1	9.4	GO:0050840	extracellular matrix binding(GO:0050840)

Showing 1 to 10 of 279 entries

Results for FOXK1_FOXP2_FOXB1_FOXP3

Z-value: 1.71

Motif logo

Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3

Activity-expression correlation:

Activity profile of FOXK1_FOXP2_FOXB1_FOXP3 motif

Sorted Z-values of FOXK1_FOXP2_FOXB1_FOXP3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category: