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ENCODE cell lines, expression (Ernst 2011)
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Results for FOXO4
Z-value: 1.73
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Transcription factors associated with FOXO4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO4 | hg19_v2_chrX_+_70316005_70316047 | -0.04 | 8.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_134551583 | 7.17 |
ENST00000435928.1 |
CALD1 |
caldesmon 1 |
| chrX_-_38080077 | 4.04 |
ENST00000378533.3 ENST00000544439.1 ENST00000432886.2 ENST00000538295.1 |
SRPX |
sushi-repeat containing protein, X-linked |
| chr7_-_95064264 | 3.72 |
ENST00000536183.1 ENST00000433091.2 ENST00000222572.3 |
PON2 |
paraoxonase 2 |
| chr3_+_159570722 | 3.35 |
ENST00000482804.1 |
SCHIP1 |
schwannomin interacting protein 1 |
| chr14_+_94577074 | 2.91 |
ENST00000444961.1 ENST00000448882.1 ENST00000557098.1 ENST00000554800.1 ENST00000556544.1 ENST00000298902.5 ENST00000555819.1 ENST00000557634.1 ENST00000555744.1 |
IFI27 |
interferon, alpha-inducible protein 27 |
| chr8_+_31497271 | 2.71 |
ENST00000520407.1 |
NRG1 |
neuregulin 1 |
| chr8_-_13134045 | 2.71 |
ENST00000512044.2 |
DLC1 |
deleted in liver cancer 1 |
| chr1_-_227505289 | 2.66 |
ENST00000366765.3 |
CDC42BPA |
CDC42 binding protein kinase alpha (DMPK-like) |
| chr11_+_844406 | 2.52 |
ENST00000397404.1 |
TSPAN4 |
tetraspanin 4 |
| chr9_+_706842 | 2.50 |
ENST00000382293.3 |
KANK1 |
KN motif and ankyrin repeat domains 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.3 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.0 | 5.2 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.5 | 4.0 | GO:0001845 | phagolysosome assembly(GO:0001845) negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.1 | 4.0 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.2 | 3.7 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.1 | 3.7 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 1.1 | 3.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 2.9 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.4 | 2.7 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.2 | 2.7 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 9.7 | GO:0042641 | actomyosin(GO:0042641) |
| 0.5 | 7.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 4.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 4.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 4.2 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.2 | 4.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 3.3 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 2.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 2.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.3 | 7.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 6.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 5.1 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.4 | 4.0 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 1.2 | 3.7 | GO:0046573 | lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007) |
| 0.2 | 3.7 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 3.6 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 3.5 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 1.1 | 3.4 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 6.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 3.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 2.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.0 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 6.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 2.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 2.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.9 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 1.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |