ISMARA results: GATA6

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ENCODE cell lines, expression (Ernst 2011)

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Results for GATA6

Z-value: 1.00

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Transcription factors associated with GATA6

Gene Symbol	Gene ID	Gene Info
GATA6 Ensembl NCBI GeneCards UniProt	ENSG00000141448.4	GATA6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA6	hg19_v2_chr18_+_19749386_19749404	0.20	4.5e-01	Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr17_-_62084241	4.01	ENST00000449662.2	ICAM2	intercellular adhesion molecule 2
chr16_+_202686	3.34	ENST00000252951.2	HBZ	hemoglobin, zeta
chr12_-_54689532	3.20	ENST00000540264.2 ENST00000312156.4	NFE2	nuclear factor, erythroid 2
chr19_-_13213662	2.62	ENST00000264824.4	LYL1	lymphoblastic leukemia derived sequence 1
chr19_+_10397621	2.17	ENST00000380770.3	ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648	2.15	ENST00000340992.4 ENST00000393717.2	ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr7_-_100239132	2.04	ENST00000223051.3 ENST00000431692.1	TFR2	transferrin receptor 2
chr11_-_116708302	1.60	ENST00000375320.1 ENST00000359492.2 ENST00000375329.2 ENST00000375323.1	APOA1	apolipoprotein A-I
chr11_+_118958689	1.51	ENST00000535253.1 ENST00000392841.1	HMBS	hydroxymethylbilane synthase
chr2_+_102928009	1.43	ENST00000404917.2 ENST00000447231.1	IL1RL1	interleukin 1 receptor-like 1

Showing 1 to 10 of 83 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.0	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2	3.3	GO:0005833	hemoglobin complex(GO:0005833)
0.0	3.0	GO:0016605	PML body(GO:0016605)
0.2	2.0	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.5	1.6	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.1	1.6	GO:0033093	Weibel-Palade body(GO:0033093)
0.2	1.4	GO:0030061	mitochondrial crista(GO:0030061)
0.1	1.4	GO:0001891	phagocytic cup(GO:0001891)
0.2	1.2	GO:0032437	cuticular plate(GO:0032437)
0.0	1.1	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Showing 1 to 10 of 20 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.5	GO:0005178	integrin binding(GO:0005178)
0.3	3.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	3.2	GO:0050699	WW domain binding(GO:0050699)
0.0	2.7	GO:0051015	actin filament binding(GO:0051015)
0.1	2.4	GO:0017127	cholesterol transporter activity(GO:0017127)
0.1	2.2	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.5	2.0	GO:0004998	transferrin receptor activity(GO:0004998)
0.4	1.6	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.1	1.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	1.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.9	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.0	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 7 of 7 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3	3.5	GO:0043249	erythrocyte maturation(GO:0043249)
0.1	3.2	GO:0006337	nucleosome disassembly(GO:0006337)
0.4	2.6	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.3	2.6	GO:0001955	blood vessel maturation(GO:0001955)
0.1	2.2	GO:0015695	organic cation transport(GO:0015695)
0.3	2.0	GO:0098707	ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0	1.5	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.5	1.4	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.1	1.4	GO:0051639	actin filament network formation(GO:0051639)

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	4.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	2.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	1.4	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	1.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	1.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	1.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	1.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 12 entries

Results for GATA6

Z-value: 1.00

Motif logo

Transcription factors associated with GATA6

Activity-expression correlation:

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category: