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ENCODE cell lines, expression (Ernst 2011)
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Results for GFI1B
Z-value: 2.16
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Transcription factors associated with GFI1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1B | hg19_v2_chr9_+_135854091_135854159 | -0.73 | 1.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1B
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149688655 | 6.70 |
ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2 |
PFN2 |
profilin 2 |
| chr9_-_14180778 | 6.12 |
ENST00000380924.1 ENST00000543693.1 |
NFIB |
nuclear factor I/B |
| chr3_-_149688896 | 6.11 |
ENST00000239940.7 |
PFN2 |
profilin 2 |
| chr10_+_124221036 | 5.29 |
ENST00000368984.3 |
HTRA1 |
HtrA serine peptidase 1 |
| chr10_+_17272608 | 5.14 |
ENST00000421459.2 |
VIM |
vimentin |
| chr6_+_12290586 | 5.12 |
ENST00000379375.5 |
EDN1 |
endothelin 1 |
| chr14_-_53417732 | 4.85 |
ENST00000399304.3 ENST00000395631.2 ENST00000341590.3 ENST00000343279.4 |
FERMT2 |
fermitin family member 2 |
| chr7_+_134576317 | 4.22 |
ENST00000424922.1 ENST00000495522.1 |
CALD1 |
caldesmon 1 |
| chr1_-_68698222 | 3.96 |
ENST00000370976.3 ENST00000354777.2 ENST00000262348.4 ENST00000540432.1 |
WLS |
wntless Wnt ligand secretion mediator |
| chr7_+_134576151 | 3.71 |
ENST00000393118.2 |
CALD1 |
caldesmon 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 6.9 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.6 | 6.5 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.2 | 6.2 | GO:0033622 | integrin activation(GO:0033622) |
| 0.9 | 6.1 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.9 | 5.7 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 1.8 | 5.5 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 1.1 | 5.3 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.6 | 5.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 1.7 | 5.1 | GO:0060585 | regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 10.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 6.6 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.2 | 6.5 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 6.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.4 | 5.5 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 5.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 4.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 12.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 10.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.3 | 8.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 8.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 6.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.4 | 5.7 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.1 | 5.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.0 | 5.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.9 | 5.1 | GO:1990254 | keratin filament binding(GO:1990254) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.7 | 10.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 6.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 6.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 5.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.8 | 5.5 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 1.3 | 5.3 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 5.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 4.9 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 4.8 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 9.1 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 7.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 6.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 5.8 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 5.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |