Project
ENCODE cell lines, expression (Ernst 2011)
Navigation
Downloads
Results for GLI3
Z-value: 1.28
Motif logo
Transcription factors associated with GLI3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg19_v2_chr7_-_42276612_42276782 | 0.41 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21529811 | 6.62 |
ENST00000588004.1 |
LAMA3 |
laminin, alpha 3 |
| chr1_-_153538292 | 4.84 |
ENST00000497140.1 ENST00000368708.3 |
S100A2 |
S100 calcium binding protein A2 |
| chr1_-_153538011 | 4.18 |
ENST00000368707.4 |
S100A2 |
S100 calcium binding protein A2 |
| chr12_-_52887034 | 3.93 |
ENST00000330722.6 |
KRT6A |
keratin 6A |
| chr20_+_62327996 | 3.86 |
ENST00000369996.1 |
TNFRSF6B |
tumor necrosis factor receptor superfamily, member 6b, decoy |
| chr17_-_39928106 | 3.74 |
ENST00000540235.1 |
JUP |
junction plakoglobin |
| chr19_+_35606692 | 3.28 |
ENST00000406242.3 ENST00000454903.2 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr12_-_52845910 | 3.20 |
ENST00000252252.3 |
KRT6B |
keratin 6B |
| chr1_+_183155373 | 3.19 |
ENST00000493293.1 ENST00000264144.4 |
LAMC2 |
laminin, gamma 2 |
| chr12_-_52867569 | 3.14 |
ENST00000252250.6 |
KRT6C |
keratin 6C |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 4.6 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 3.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 2.6 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.3 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 2.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.3 | 8.1 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.3 | 5.4 | GO:0048817 | negative regulation of hair follicle maturation(GO:0048817) |
| 1.3 | 3.9 | GO:0051710 | regulation of cytolysis in other organism(GO:0051710) |
| 0.7 | 3.7 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.0 | 3.4 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.1 | 3.2 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.5 | 3.1 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.1 | 3.1 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.2 | 3.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 8.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 6.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 3.7 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.6 | 3.6 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.4 | 3.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 2.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.4 | 2.7 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.2 | 2.4 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 2.4 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | GO:0045095 | keratin filament(GO:0045095) |
| 1.2 | 8.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.8 | 6.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 4.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 4.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.5 | 3.9 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.1 | 3.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.1 | 3.2 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.1 | 3.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 3.1 | GO:0030056 | hemidesmosome(GO:0030056) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 8.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 3.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 3.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 2.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 2.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.5 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 2.1 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 1.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |