ISMARA results: HNF1A

Project

ENCODE cell lines, expression (Ernst 2011)

Navigation

Downloads

Results for HNF1A_HNF1B

Z-value: 4.44

Motif logo

Transcription factors associated with HNF1A_HNF1B

Gene Symbol	Gene ID	Gene Info
HNF1A Ensembl NCBI GeneCards UniProt	ENSG00000135100.13	HNF1A
HNF1B Ensembl NCBI GeneCards UniProt	ENSG00000108753.8	HNF1B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF1A	hg19_v2_chr12_+_121416489_121416552	0.97	1.6e-10	Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr4_+_74301880	66.80	ENST00000395792.2 ENST00000226359.2	AFP	alpha-fetoprotein
chr17_-_64225508	41.88	ENST00000205948.6	APOH	apolipoprotein H (beta-2-glycoprotein I)
chrX_-_105282712	27.11	ENST00000372563.1	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_123812542	25.50	ENST00000223642.1	C5	complement component 5
chr4_-_110723335	22.70	ENST00000394634.2	CFI	complement factor I
chr4_-_155511887	22.56	ENST00000302053.3 ENST00000403106.3	FGA	fibrinogen alpha chain
chr4_-_110723194	22.18	ENST00000394635.3	CFI	complement factor I
chr4_-_110723134	22.14	ENST00000510800.1 ENST00000512148.1	CFI	complement factor I
chr14_-_94854926	18.80	ENST00000402629.1 ENST00000556091.1 ENST00000554720.1	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_5135981	17.37	ENST00000380554.3	AKR1C3	aldo-keto reductase family 1, member C3

Showing 1 to 10 of 143 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	97.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.0	64.8	GO:0005044	scavenger receptor activity(GO:0005044)
8.4	41.9	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
2.9	31.7	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.3	29.3	GO:0051087	chaperone binding(GO:0051087)
2.6	25.5	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.5	24.7	GO:0008009	chemokine activity(GO:0008009)
0.1	20.5	GO:0030674	protein binding, bridging(GO:0030674)
6.4	19.1	GO:1902122	chenodeoxycholic acid binding(GO:1902122)
1.5	18.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)

Showing 1 to 10 of 61 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	208.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
5.6	72.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	50.6	GO:0005615	extracellular space(GO:0005615)
2.7	47.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.4	40.3	GO:0044215	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	37.4	GO:0030133	transport vesicle(GO:0030133)
3.0	27.2	GO:0005579	membrane attack complex(GO:0005579)
0.5	19.1	GO:0005719	nuclear euchromatin(GO:0005719)
2.6	18.0	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	14.8	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	129.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	69.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.0	54.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.7	49.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	32.7	PID FGF PATHWAY	FGF signaling pathway
0.4	19.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.3	15.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	12.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	10.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	9.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.0	112.8	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
3.4	50.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
1.4	34.9	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.2	26.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.2	26.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.8	25.5	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.2	20.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.9	16.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.4	14.7	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	12.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 28 entries

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	68.7	GO:0006958	complement activation, classical pathway(GO:0006958)
4.5	66.8	GO:0001542	ovulation from ovarian follicle(GO:0001542)
5.4	59.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
5.4	54.2	GO:0043152	induction of bacterial agglutination(GO:0043152)
5.1	45.8	GO:0045959	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
5.7	40.0	GO:0008218	bioluminescence(GO:0008218)
0.9	31.7	GO:0036499	PERK-mediated unfolded protein response(GO:0036499)
2.2	26.4	GO:0070327	thyroid hormone transport(GO:0070327)
8.5	25.5	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
5.1	25.5	GO:1903412	response to bile acid(GO:1903412)

Showing 1 to 10 of 71 entries

Results for HNF1A_HNF1B

Z-value: 4.44

Motif logo

Transcription factors associated with HNF1A_HNF1B

Activity-expression correlation:

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category: