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ENCODE cell lines, expression (Ernst 2011)
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Results for HNF4G
Z-value: 1.68
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Transcription factors associated with HNF4G
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4G | hg19_v2_chr8_+_76452097_76452126 | 0.25 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4G
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_6720686 | 4.65 |
ENST00000245907.6 |
C3 |
complement component 3 |
| chr17_-_7082668 | 4.48 |
ENST00000573083.1 ENST00000574388.1 |
ASGR1 |
asialoglycoprotein receptor 1 |
| chr17_-_7082861 | 3.73 |
ENST00000269299.3 |
ASGR1 |
asialoglycoprotein receptor 1 |
| chr1_-_169555779 | 3.52 |
ENST00000367797.3 ENST00000367796.3 |
F5 |
coagulation factor V (proaccelerin, labile factor) |
| chr17_+_27369918 | 3.50 |
ENST00000323372.4 |
PIPOX |
pipecolic acid oxidase |
| chr11_-_2158507 | 3.33 |
ENST00000381392.1 ENST00000381395.1 ENST00000418738.2 |
IGF2 |
insulin-like growth factor 2 (somatomedin A) |
| chr13_+_113760098 | 3.12 |
ENST00000346342.3 ENST00000541084.1 ENST00000375581.3 |
F7 |
coagulation factor VII (serum prothrombin conversion accelerator) |
| chr14_-_94854926 | 3.12 |
ENST00000402629.1 ENST00000556091.1 ENST00000554720.1 |
SERPINA1 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| chr8_-_27468842 | 3.01 |
ENST00000523500.1 |
CLU |
clusterin |
| chr8_-_27469196 | 2.85 |
ENST00000546343.1 ENST00000560566.1 |
CLU |
clusterin |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 1.4 | 8.2 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 2.4 | 7.3 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 1.4 | 6.8 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 1.3 | 6.6 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.7 | 5.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.5 | 4.7 | GO:1903027 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 1.5 | 4.6 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.2 | 4.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 4.4 | GO:0036499 | PERK-mediated unfolded protein response(GO:0036499) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.0 | 8.2 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.4 | 8.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.5 | 7.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 6.5 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.0 | 6.0 | GO:0003779 | actin binding(GO:0003779) |
| 1.1 | 5.5 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.5 | 5.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 4.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 4.5 | GO:0031014 | troponin T binding(GO:0031014) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 6.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 4.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 3.5 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 3.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 11.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 10.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 9.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 6.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 5.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 3.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 3.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 11.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.4 | 11.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.8 | 8.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 7.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 7.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 5.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 4.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 3.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 3.7 | GO:0030027 | lamellipodium(GO:0030027) |