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ENCODE cell lines, expression (Ernst 2011)
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Results for HOXB4_LHX9
Z-value: 1.66
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Transcription factors associated with HOXB4_LHX9
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB4_LHX9
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_169418195 | 17.92 |
ENST00000261509.6 ENST00000335742.7 |
PALLD |
palladin, cytoskeletal associated protein |
| chr17_-_39743139 | 11.85 |
ENST00000167586.6 |
KRT14 |
keratin 14 |
| chr4_+_169418255 | 8.27 |
ENST00000505667.1 ENST00000511948.1 |
PALLD |
palladin, cytoskeletal associated protein |
| chr14_-_67878917 | 6.99 |
ENST00000216446.4 |
PLEK2 |
pleckstrin 2 |
| chr12_-_8803128 | 6.80 |
ENST00000543467.1 |
MFAP5 |
microfibrillar associated protein 5 |
| chr10_-_105845674 | 5.98 |
ENST00000353479.5 ENST00000369733.3 |
COL17A1 |
collagen, type XVII, alpha 1 |
| chr11_+_5710919 | 5.55 |
ENST00000379965.3 ENST00000425490.1 |
TRIM22 |
tripartite motif containing 22 |
| chr7_+_134528635 | 5.05 |
ENST00000445569.2 |
CALD1 |
caldesmon 1 |
| chr8_-_41166953 | 4.52 |
ENST00000220772.3 |
SFRP1 |
secreted frizzled-related protein 1 |
| chr4_+_169552748 | 4.52 |
ENST00000504519.1 ENST00000512127.1 |
PALLD |
palladin, cytoskeletal associated protein |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 6.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 6.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 4.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 3.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 3.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 2.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.1 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 2.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 30.7 | GO:0003334 | keratinocyte development(GO:0003334) |
| 2.0 | 11.8 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.4 | 11.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 8.3 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 6.8 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.9 | 6.4 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.1 | 5.4 | GO:0070206 | protein trimerization(GO:0070206) |
| 1.7 | 5.2 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.5 | 4.9 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 1.5 | 4.5 | GO:0090244 | Wnt signaling pathway involved in somitogenesis(GO:0090244) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 8.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 6.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 4.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 3.2 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 30.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 2.0 | 11.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 8.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 7.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 6.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 6.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 6.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 6.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 5.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 3.6 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 30.7 | GO:0002102 | podosome(GO:0002102) |
| 0.3 | 11.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 7.0 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.7 | 6.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.3 | 6.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.9 | 6.4 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.3 | 6.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 5.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.7 | 5.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 5.5 | GO:0015030 | Cajal body(GO:0015030) |