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ENCODE cell lines, expression (Ernst 2011)
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Results for HOXB6_PRRX2
Z-value: 1.92
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB6 | hg19_v2_chr17_-_46682321_46682362 | 0.77 | 5.1e-04 | Click! |
| PRRX2 | hg19_v2_chr9_+_132427883_132427951 | 0.19 | 4.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_175711133 | 9.34 |
ENST00000409597.1 ENST00000413882.1 |
CHN1 |
chimerin 1 |
| chr7_-_27205136 | 9.07 |
ENST00000396345.1 ENST00000343483.6 |
HOXA9 |
homeobox A9 |
| chr12_-_91576561 | 7.89 |
ENST00000547568.2 ENST00000552962.1 |
DCN |
decorin |
| chr12_-_91576750 | 7.75 |
ENST00000228329.5 ENST00000303320.3 ENST00000052754.5 |
DCN |
decorin |
| chr18_-_53089723 | 7.25 |
ENST00000561992.1 ENST00000562512.2 |
TCF4 |
transcription factor 4 |
| chrX_+_135251783 | 6.95 |
ENST00000394153.2 |
FHL1 |
four and a half LIM domains 1 |
| chr12_-_91576429 | 6.84 |
ENST00000552145.1 ENST00000546745.1 |
DCN |
decorin |
| chr3_+_159557637 | 6.70 |
ENST00000445224.2 |
SCHIP1 |
schwannomin interacting protein 1 |
| chr3_-_114477787 | 6.22 |
ENST00000464560.1 |
ZBTB20 |
zinc finger and BTB domain containing 20 |
| chr3_+_158787041 | 6.12 |
ENST00000471575.1 ENST00000476809.1 ENST00000485419.1 |
IQCJ-SCHIP1 |
IQCJ-SCHIP1 readthrough |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.6 | 32.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 18.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 11.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 8.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 6.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 5.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.8 | 23.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 19.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 12.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.2 | 10.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 9.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 8.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 8.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 8.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 8.2 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 35.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.3 | 34.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 12.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 7.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 6.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 6.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 5.8 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.4 | 5.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 5.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 5.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 61.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 2.2 | 31.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 20.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 13.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.1 | 11.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.7 | 9.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 7.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 6.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.4 | 5.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 5.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 31.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.5 | 27.9 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 22.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.3 | 15.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.4 | 12.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.5 | 10.3 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.7 | 8.9 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 2.2 | 6.7 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.6 | 6.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 6.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |