ISMARA results: HOXD1

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ENCODE cell lines, expression (Ernst 2011)

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Results for HOXD1

Z-value: 0.62

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Transcription factors associated with HOXD1

Gene Symbol	Gene ID	Gene Info
HOXD1 Ensembl NCBI GeneCards UniProt	ENSG00000128645.11	HOXD1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD1	hg19_v2_chr2_+_177053307_177053402	-0.46	7.6e-02	Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr15_-_55563072	1.14	ENST00000567380.1 ENST00000565972.1 ENST00000569493.1	RAB27A	RAB27A, member RAS oncogene family
chr11_-_62521614	1.12	ENST00000527994.1 ENST00000394807.3	ZBTB3	zinc finger and BTB domain containing 3
chr15_-_55562479	1.07	ENST00000564609.1	RAB27A	RAB27A, member RAS oncogene family
chr8_-_49834299	1.02	ENST00000396822.1	SNAI2	snail family zinc finger 2
chr4_-_25865159	1.00	ENST00000502949.1 ENST00000264868.5 ENST00000513691.1 ENST00000514872.1	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chr12_+_29376673	0.97	ENST00000547116.1	FAR2	fatty acyl CoA reductase 2
chr12_+_29376592	0.95	ENST00000182377.4	FAR2	fatty acyl CoA reductase 2
chr3_-_151034734	0.93	ENST00000260843.4	GPR87	G protein-coupled receptor 87
chr8_-_49833978	0.91	ENST00000020945.1	SNAI2	snail family zinc finger 2
chr11_-_102651343	0.87	ENST00000279441.4 ENST00000539681.1	MMP10	matrix metallopeptidase 10 (stromelysin 2)

Showing 1 to 10 of 49 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	2.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	2.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.0	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.6	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.6	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	1.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	1.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.3	1.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion

Showing 1 to 10 of 32 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
0.6	2.5	GO:0071461	cellular response to redox state(GO:0071461)
0.0	2.5	GO:0002820	negative regulation of adaptive immune response(GO:0002820)
0.2	2.0	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713)
0.4	1.8	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	1.8	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	1.6	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	1.6	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.0	1.6	GO:0030449	regulation of complement activation(GO:0030449)
0.0	1.6	GO:0031532	actin cytoskeleton reorganization(GO:0031532)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0031489	myosin V binding(GO:0031489)
0.6	1.9	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0	1.9	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	1.4	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.6	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.3	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1	0.2	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.0	0.1	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	26.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	12.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	12.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	11.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3	6.0	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	5.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	4.4	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.2	4.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	3.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	2.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

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Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0042100	B cell proliferation(GO:0042100)
0.2	3.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.6	2.9	GO:0002399	MHC class II protein complex assembly(GO:0002399)
0.1	2.5	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.0	2.1	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	1.7	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	1.5	GO:0038096	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0	1.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.2	1.2	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.3	1.0	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)

Showing 1 to 10 of 86 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	5.8	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2	2.3	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0	1.4	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.1	1.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	1.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	1.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	1.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	0.9	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2	0.7	GO:0061752	telomeric repeat-containing RNA binding(GO:0061752)
0.0	0.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)

Showing 1 to 10 of 95 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	18.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	16.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	12.3	NABA COLLAGENS	Genes encoding collagen proteins
0.1	11.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	10.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	9.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	5.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	4.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	2.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling

Showing 1 to 10 of 36 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.0	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	4.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	3.9	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.7	GO:0001772	immunological synapse(GO:0001772)
0.3	1.6	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.1	1.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.2	0.6	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1	0.6	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0	0.6	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.5	GO:0001533	cornified envelope(GO:0001533)

Showing 1 to 10 of 36 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	21.7	GO:0030478	actin cap(GO:0030478)
1.1	16.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	8.2	GO:0000790	nuclear chromatin(GO:0000790)
0.1	7.3	GO:0001533	cornified envelope(GO:0001533)
0.5	6.5	GO:0005577	fibrinogen complex(GO:0005577)
0.0	6.3	GO:0005925	focal adhesion(GO:0005925)
0.1	6.2	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
2.0	6.1	GO:0005588	collagen type V trimer(GO:0005588)
0.1	5.4	GO:0031594	neuromuscular junction(GO:0031594)
0.6	5.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	1.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	1.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.6	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.2	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	21.7	GO:0005523	tropomyosin binding(GO:0005523)
0.2	21.3	GO:0005518	collagen binding(GO:0005518)
0.1	13.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	13.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7	11.7	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	5.7	GO:0008201	heparin binding(GO:0008201)
0.1	5.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.1	5.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
1.3	5.1	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.4	4.4	GO:0005176	ErbB-2 class receptor binding(GO:0005176)

Showing 1 to 10 of 122 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.8	GO:0006825	copper ion transport(GO:0006825)
0.0	2.7	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.1	1.1	GO:0035799	ureter maturation(GO:0035799)
0.2	1.0	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	1.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	0.9	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1	0.8	GO:0071233	cellular response to leucine(GO:0071233)
0.2	0.7	GO:0046098	guanine metabolic process(GO:0046098)
0.1	0.7	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.7	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)

Showing 1 to 10 of 138 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	1.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	1.3	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	1.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	1.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	1.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.1	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	2.1	GO:0042605	peptide antigen binding(GO:0042605)
0.0	2.0	GO:0003823	antigen binding(GO:0003823)
0.1	1.8	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0	1.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	1.7	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	1.6	GO:0050700	CARD domain binding(GO:0050700)
0.3	1.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	0.9	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.8	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Showing 1 to 10 of 54 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0032993	protein-DNA complex(GO:0032993)
0.0	2.7	GO:0016459	myosin complex(GO:0016459)
0.2	2.0	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.5	1.9	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.6	1.8	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.1	1.8	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.2	1.6	GO:0097452	GAIT complex(GO:0097452)
0.1	1.5	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2	1.3	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	1.2	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

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Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.9	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	1.9	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	1.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	1.6	GO:0005680	anaphase-promoting complex(GO:0005680)

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Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.2	GO:0032993	protein-DNA complex(GO:0032993)
0.1	0.9	GO:0033093	Weibel-Palade body(GO:0033093)
0.2	0.7	GO:1990423	RZZ complex(GO:1990423)
0.1	0.7	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.7	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.7	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.6	GO:0032982	myosin filament(GO:0032982)
0.1	0.5	GO:0030870	Mre11 complex(GO:0030870)

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
2.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
2.2	PID ILK PATHWAY	Integrin-linked kinase signaling
1.3	PID ATM PATHWAY	ATM pathway
1.3	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
1.2	PID S1P S1P3 PATHWAY	S1P3 pathway
1.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.0	PID AURORA B PATHWAY	Aurora B signaling
0.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.8	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2	2.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7	2.0	GO:0032089	NACHT domain binding(GO:0032089)
0.2	2.0	GO:0032027	myosin light chain binding(GO:0032027)
0.6	1.9	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.4	1.8	GO:0070026	nitric oxide binding(GO:0070026)
0.1	1.6	GO:0035613	RNA stem-loop binding(GO:0035613)
0.2	1.5	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1	1.5	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	1.5	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Showing 1 to 10 of 84 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.1	PID ILK PATHWAY	Integrin-linked kinase signaling
1.0	ST JNK MAPK PATHWAY	JNK MAPK Pathway
1.0	PID E2F PATHWAY	E2F transcription factor network
0.7	PID BARD1 PATHWAY	BARD1 signaling events
0.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 10 of 12 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.9	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.6	1.9	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.6	1.9	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1	1.6	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.2	1.4	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.9	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.9	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.6	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.6	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.4	GO:0051639	actin filament network formation(GO:0051639)

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Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

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Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.6	GO:0006936	muscle contraction(GO:0006936)
1.1	12.9	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
3.9	11.7	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2	11.0	GO:0010107	potassium ion import(GO:0010107)
2.4	7.1	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1	6.4	GO:0030574	collagen catabolic process(GO:0030574)
1.5	6.1	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.1	6.0	GO:0018149	peptide cross-linking(GO:0018149)
1.7	5.1	GO:0002514	B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.6	4.5	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)

Showing 1 to 10 of 165 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.8	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	2.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.0	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.0	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.7	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.7	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	1.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	1.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	1.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.9	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 8 of 8 entries

Results for HOXD1

Z-value: 0.62

Motif logo

Transcription factors associated with HOXD1

Activity-expression correlation:

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category: