ISMARA results: ID4_TCF4

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ENCODE cell lines, expression (Ernst 2011)

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Results for ID4_TCF4_SNAI2

Z-value: 2.63

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Transcription factors associated with ID4_TCF4_SNAI2

Gene Symbol	Gene ID	Gene Info
ID4 Ensembl NCBI GeneCards UniProt	ENSG00000172201.6	ID4
TCF4 Ensembl NCBI GeneCards UniProt	ENSG00000196628.9	TCF4
SNAI2 Ensembl NCBI GeneCards UniProt	ENSG00000019549.4	SNAI2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF4	hg19_v2_chr18_-_53068911_53068935	-0.55	2.6e-02	Click!
SNAI2	hg19_v2_chr8_-_49833978_49833996, hg19_v2_chr8_-_49834299_49834446	-0.49	5.5e-02	Click!
ID4	hg19_v2_chr6_+_19837592_19837621	0.06	8.3e-01	Click!

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

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Promoter	Score	Transcript	Gene	Gene Info
chr18_+_29077990	10.23	ENST00000261590.8	DSG2	desmoglein 2
chr14_+_31343951	7.01	ENST00000556908.1 ENST00000555881.1 ENST00000460581.2	COCH	cochlin
chr14_+_31343747	6.92	ENST00000216361.4 ENST00000396618.3 ENST00000475087.1	COCH	cochlin
chr14_-_55369525	6.10	ENST00000543643.2 ENST00000536224.2 ENST00000395514.1 ENST00000491895.2	GCH1	GTP cyclohydrolase 1
chr1_+_60280458	5.56	ENST00000455990.1 ENST00000371208.3	HOOK1	hook microtubule-tethering protein 1
chr2_+_47596287	5.33	ENST00000263735.4	EPCAM	epithelial cell adhesion molecule
chr12_+_56473628	4.70	ENST00000549282.1 ENST00000549061.1 ENST00000267101.3	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr17_+_73521763	4.55	ENST00000167462.5 ENST00000375227.4 ENST00000392550.3 ENST00000578363.1 ENST00000579392.1	LLGL2	lethal giant larvae homolog 2 (Drosophila)
chr4_-_40631859	4.53	ENST00000295971.7 ENST00000319592.4	RBM47	RNA binding motif protein 47
chrX_+_115567767	4.19	ENST00000371900.4	SLC6A14	solute carrier family 6 (amino acid transporter), member 14

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	29.4	GO:0042571	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.6	20.2	GO:0030057	desmosome(GO:0030057)
0.1	19.4	GO:0031965	nuclear membrane(GO:0031965)
0.2	15.6	GO:0016328	lateral plasma membrane(GO:0016328)
2.4	14.6	GO:0061689	tricellular tight junction(GO:0061689)
0.0	14.0	GO:0005730	nucleolus(GO:0005730)
0.1	11.4	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.2	9.9	GO:0045095	keratin filament(GO:0045095)
1.0	8.0	GO:0045179	apical cortex(GO:0045179)
0.0	7.6	GO:0031968	organelle outer membrane(GO:0031968)

Showing 1 to 10 of 347 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	15.6	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5	10.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	9.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4	7.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	7.8	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	7.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.7	7.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	6.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	5.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	5.4	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions

Showing 1 to 10 of 171 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	28.5	GO:0006910	phagocytosis, recognition(GO:0006910)
2.2	19.5	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
2.9	14.6	GO:1904274	tricellular tight junction assembly(GO:1904274)
0.1	14.0	GO:0030183	B cell differentiation(GO:0030183)
0.1	9.0	GO:0002431	Fc receptor mediated stimulatory signaling pathway(GO:0002431)
1.2	7.4	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.1	6.7	GO:0045576	mast cell activation(GO:0045576)
2.2	6.6	GO:0051066	dihydrobiopterin metabolic process(GO:0051066)
0.2	6.6	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
1.2	6.2	GO:0042100	B cell proliferation(GO:0042100)

Showing 1 to 10 of 1,028 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	30.6	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.2	19.5	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.6	12.0	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.1	9.6	GO:0030165	PDZ domain binding(GO:0030165)
0.2	9.2	GO:0042169	SH2 domain binding(GO:0042169)
0.5	7.0	GO:0038132	neuregulin binding(GO:0038132)
0.5	7.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2	6.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	6.5	GO:0017080	sodium channel regulator activity(GO:0017080)
1.0	6.3	GO:0019238	cyclohydrolase activity(GO:0019238)

Showing 1 to 10 of 621 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	14.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	12.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.2	9.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	8.0	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	7.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	6.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	6.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	5.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	4.6	PID BCR 5PATHWAY	BCR signaling pathway

Showing 1 to 10 of 109 entries

Results for ID4_TCF4_SNAI2

Z-value: 2.63

Motif logo

Transcription factors associated with ID4_TCF4_SNAI2

Activity-expression correlation:

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category: