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ENCODE cell lines, expression (Ernst 2011)
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Results for IKZF1
Z-value: 2.26
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg19_v2_chr7_+_50344289_50344378 | -0.84 | 4.1e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_35247859 | 6.08 |
ENST00000373362.3 |
GJB3 |
gap junction protein, beta 3, 31kDa |
| chr15_+_63334831 | 5.13 |
ENST00000288398.6 ENST00000358278.3 ENST00000560445.1 ENST00000403994.3 ENST00000357980.4 ENST00000559556.1 ENST00000559397.1 ENST00000267996.7 ENST00000560970.1 |
TPM1 |
tropomyosin 1 (alpha) |
| chr1_-_153538292 | 4.98 |
ENST00000497140.1 ENST00000368708.3 |
S100A2 |
S100 calcium binding protein A2 |
| chr1_-_153538011 | 4.89 |
ENST00000368707.4 |
S100A2 |
S100 calcium binding protein A2 |
| chr16_+_56716336 | 4.81 |
ENST00000394485.4 ENST00000562939.1 |
MT1X |
metallothionein 1X |
| chr3_-_149095652 | 4.79 |
ENST00000305366.3 |
TM4SF1 |
transmembrane 4 L six family member 1 |
| chr19_-_51456321 | 4.66 |
ENST00000391809.2 |
KLK5 |
kallikrein-related peptidase 5 |
| chr19_-_51456344 | 4.62 |
ENST00000336334.3 ENST00000593428.1 |
KLK5 |
kallikrein-related peptidase 5 |
| chr1_-_153599732 | 4.44 |
ENST00000392623.1 |
S100A13 |
S100 calcium binding protein A13 |
| chr17_-_39928106 | 4.43 |
ENST00000540235.1 |
JUP |
junction plakoglobin |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 31.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.4 | 27.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.3 | 24.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 22.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 18.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 2.5 | 17.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.4 | 15.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 15.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.7 | 15.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 42.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 35.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 21.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 17.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 13.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 11.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 9.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.3 | 9.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 8.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.6 | 8.4 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 44.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 36.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 30.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 26.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 25.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.8 | 15.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 12.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 11.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 10.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 10.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 54.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 46.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 22.1 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.9 | 21.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 14.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 13.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 12.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 12.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 11.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 11.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 32.5 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 1.1 | 31.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 31.6 | GO:0070268 | cornification(GO:0070268) |
| 2.8 | 22.5 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 1.1 | 20.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 2.9 | 17.4 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.3 | 14.5 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 0.2 | 14.0 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.3 | 13.9 | GO:0097435 | fibril organization(GO:0097435) |
| 1.2 | 11.2 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |