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ENCODE cell lines, expression (Ernst 2011)
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Results for IKZF2
Z-value: 1.22
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Transcription factors associated with IKZF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF2 | hg19_v2_chr2_-_214014959_214015058 | 0.14 | 6.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_189839046 | 5.03 |
ENST00000304636.3 ENST00000317840.5 |
COL3A1 |
collagen, type III, alpha 1 |
| chr12_-_91573316 | 3.55 |
ENST00000393155.1 |
DCN |
decorin |
| chr1_-_57045228 | 3.51 |
ENST00000371250.3 |
PPAP2B |
phosphatidic acid phosphatase type 2B |
| chr2_-_190044480 | 3.37 |
ENST00000374866.3 |
COL5A2 |
collagen, type V, alpha 2 |
| chr13_-_38172863 | 3.22 |
ENST00000541481.1 ENST00000379743.4 ENST00000379742.4 ENST00000379749.4 ENST00000541179.1 ENST00000379747.4 |
POSTN |
periostin, osteoblast specific factor |
| chr12_-_91573132 | 3.17 |
ENST00000550563.1 ENST00000546370.1 |
DCN |
decorin |
| chr12_-_91573249 | 3.14 |
ENST00000550099.1 ENST00000546391.1 ENST00000551354.1 |
DCN |
decorin |
| chr7_+_93551011 | 2.39 |
ENST00000248564.5 |
GNG11 |
guanine nucleotide binding protein (G protein), gamma 11 |
| chr1_-_153518270 | 2.35 |
ENST00000354332.4 ENST00000368716.4 |
S100A4 |
S100 calcium binding protein A4 |
| chr1_+_101185290 | 2.23 |
ENST00000370119.4 ENST00000347652.2 ENST00000294728.2 ENST00000370115.1 |
VCAM1 |
vascular cell adhesion molecule 1 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.6 | 5.0 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 1.1 | 3.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 3.1 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 3.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 2.9 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 2.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.7 | 2.2 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.4 | 1.9 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 1.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 8.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.7 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.0 | 2.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 1.9 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 1.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.9 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 4.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 4.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 3.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.3 | 2.9 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 2.5 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 2.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 2.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 1.9 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 1.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 8.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 4.9 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 2.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.9 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.6 | 5.0 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 4.6 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 4.5 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.8 | 3.4 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 1.1 | 3.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.2 | 3.2 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 2.4 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.4 | 2.2 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.6 | 1.9 | GO:1905066 | arterial endothelial cell fate commitment(GO:0060844) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |