ISMARA results: IRF2_STAT2_IRF8

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ENCODE cell lines, expression (Ernst 2011)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 4.88

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt	ENSG00000168310.6	IRF2
STAT2 Ensembl NCBI GeneCards UniProt	ENSG00000170581.9	STAT2
IRF8 Ensembl NCBI GeneCards UniProt	ENSG00000140968.6	IRF8
IRF1 Ensembl NCBI GeneCards UniProt	ENSG00000125347.9	IRF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF8	hg19_v2_chr16_+_85942594_85942635	0.85	3.3e-05	Click!
IRF2	hg19_v2_chr4_-_185395672_185395734	0.84	5.3e-05	Click!
IRF1	hg19_v2_chr5_-_131826457_131826514	0.83	7.0e-05	Click!
STAT2	hg19_v2_chr12_-_56753858_56753930	-0.12	6.6e-01	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_79086088	39.26	ENST00000370751.5 ENST00000342282.3	IFI44L	interferon-induced protein 44-like
chr21_+_42792442	24.81	ENST00000398600.2	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_32821924	23.87	ENST00000374859.2 ENST00000453265.2	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr10_+_91152303	22.66	ENST00000371804.3	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr1_+_948803	22.47	ENST00000379389.4	ISG15	ISG15 ubiquitin-like modifier
chr11_-_615942	20.09	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7	interferon regulatory factor 7
chr4_+_89378261	18.72	ENST00000264350.3	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr16_+_12058961	17.15	ENST00000053243.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr1_+_79115503	16.52	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44	interferon-induced protein 44
chr16_+_12059050	16.12	ENST00000396495.3	TNFRSF17	tumor necrosis factor receptor superfamily, member 17

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	69.0	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
7.5	59.8	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.5	58.7	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
1.1	53.6	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
4.6	50.6	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.3	49.7	GO:0006906	vesicle fusion(GO:0006906)
0.7	41.6	GO:0002260	lymphocyte homeostasis(GO:0002260)
6.9	34.6	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
2.7	29.5	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
8.8	26.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)

Showing 1 to 10 of 244 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	82.5	GO:0005525	GTP binding(GO:0005525)
0.3	81.9	GO:0001047	core promoter binding(GO:0001047)
1.9	56.2	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.4	42.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3	34.9	GO:0003727	single-stranded RNA binding(GO:0003727)
3.5	34.5	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
5.3	31.6	GO:0042296	ISG15 transferase activity(GO:0042296)
0.3	26.9	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
8.8	26.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	25.2	GO:0008270	zinc ion binding(GO:0008270)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	64.6	GO:0005739	mitochondrion(GO:0005739)
7.5	60.4	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	52.2	GO:0016607	nuclear speck(GO:0016607)
0.1	38.9	GO:0031965	nuclear membrane(GO:0031965)
0.5	37.9	GO:0015030	Cajal body(GO:0015030)
0.4	29.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	29.5	GO:0000790	nuclear chromatin(GO:0000790)
0.0	27.5	GO:0005768	endosome(GO:0005768)
0.1	22.3	GO:0009897	external side of plasma membrane(GO:0009897)
2.9	20.2	GO:0036021	endolysosome lumen(GO:0036021)

Showing 1 to 10 of 100 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	43.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.7	24.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.3	22.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.3	21.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.7	20.5	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	19.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	12.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.4	10.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	10.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	9.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	290.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.8	58.2	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
1.1	56.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	18.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.2	17.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.6	16.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.8	16.0	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	12.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.6	11.6	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.1	11.3	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades

Showing 1 to 10 of 67 entries

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 4.88

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: