ISMARA results: IRF6_IRF4

Project

ENCODE cell lines, expression (Ernst 2011)

Navigation

Downloads

Results for IRF6_IRF4_IRF5

Z-value: 1.47

Motif logo

Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol	Gene ID	Gene Info
IRF6 Ensembl NCBI GeneCards UniProt	ENSG00000117595.6	IRF6
IRF4 Ensembl NCBI GeneCards UniProt	ENSG00000137265.10	IRF4
IRF5 Ensembl NCBI GeneCards UniProt	ENSG00000128604.14	IRF5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF6	hg19_v2_chr1_-_209979375_209979389	0.62	1.1e-02	Click!
IRF5	hg19_v2_chr7_+_128577972_128578047	0.31	2.5e-01	Click!
IRF4	hg19_v2_chr6_+_391739_391759	0.29	2.7e-01	Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr21_+_42792442	5.88	ENST00000398600.2	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582	5.15	ENST00000202917.5 ENST00000445409.2 ENST00000452357.2	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798094	4.27	ENST00000398598.3 ENST00000455164.2 ENST00000424365.1	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344755	4.27	ENST00000550883.1	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr9_-_32526184	4.18	ENST00000545044.1 ENST00000379868.1	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526299	4.14	ENST00000379882.1 ENST00000379883.2	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_-_59043166	3.89	ENST00000371225.2	TACSTD2	tumor-associated calcium signal transducer 2
chr11_-_615942	3.81	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7	interferon regulatory factor 7
chr11_-_104817919	3.12	ENST00000533252.1	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr11_-_118134997	3.07	ENST00000278937.2	MPZL2	myelin protein zero-like 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.8	14.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	3.7	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	3.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	2.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	1.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.0	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.9	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.7	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling

Showing 1 to 10 of 17 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	3.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	2.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	1.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	1.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	1.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	0.9	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Showing 1 to 10 of 17 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.8	GO:0031965	nuclear membrane(GO:0031965)
0.1	8.1	GO:0032587	ruffle membrane(GO:0032587)
0.0	6.0	GO:0045121	membrane raft(GO:0045121)
0.1	4.8	GO:0009925	basal plasma membrane(GO:0009925)
0.3	3.5	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.5	3.1	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	2.6	GO:0015030	Cajal body(GO:0015030)
0.0	1.4	GO:0005882	intermediate filament(GO:0005882)
0.1	1.1	GO:0097208	alveolar lamellar body(GO:0097208)
0.0	0.9	GO:0042613	MHC class II protein complex(GO:0042613)

Showing 1 to 10 of 24 entries

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.9	GO:0045071	negative regulation of viral genome replication(GO:0045071)
1.0	10.9	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
2.3	9.3	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.9	7.2	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.7	5.4	GO:0032020	ISG15-protein conjugation(GO:0032020)
1.1	5.3	GO:2000110	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.5	3.9	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.3	3.5	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.0	3.4	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.3	3.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)

Showing 1 to 10 of 63 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	12.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	11.2	GO:0008017	microtubule binding(GO:0008017)
0.1	9.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.7	7.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	6.8	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6	3.7	GO:0042296	ISG15 transferase activity(GO:0042296)
0.2	3.5	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2	3.1	GO:0050700	CARD domain binding(GO:0050700)
0.2	2.0	GO:0031386	protein tag(GO:0031386)
0.4	1.9	GO:0004771	sterol esterase activity(GO:0004771)

Showing 1 to 10 of 48 entries

Results for IRF6_IRF4_IRF5

Z-value: 1.47

Motif logo

Transcription factors associated with IRF6_IRF4_IRF5

Activity-expression correlation:

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category: