ISMARA results: JUN

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ENCODE cell lines, expression (Ernst 2011)

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Results for JUN

Z-value: 1.76

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Transcription factors associated with JUN

Gene Symbol	Gene ID	Gene Info
JUN Ensembl NCBI GeneCards UniProt	ENSG00000177606.5	JUN

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUN	hg19_v2_chr1_-_59249732_59249785	0.79	2.7e-04	Click!

Activity profile of JUN motif

Sorted Z-values of JUN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Promoter	Score	Transcript	Gene	Gene Info
chr5_-_54281407	5.66	ENST00000381403.4	ESM1	endothelial cell-specific molecule 1
chr6_+_139456226	5.42	ENST00000367658.2	HECA	headcase homolog (Drosophila)
chr11_+_117070037	4.47	ENST00000392951.4 ENST00000525531.1 ENST00000278968.6	TAGLN	transgelin
chr2_-_216300784	4.47	ENST00000421182.1 ENST00000432072.2 ENST00000323926.6 ENST00000336916.4 ENST00000357867.4 ENST00000359671.1 ENST00000346544.3 ENST00000345488.5 ENST00000357009.2 ENST00000446046.1 ENST00000356005.4 ENST00000443816.1 ENST00000426059.1 ENST00000354785.4	FN1	fibronectin 1
chr17_-_76899275	4.30	ENST00000322630.2 ENST00000586713.1	DDC8	Protein DDC8 homolog
chrX_-_101771645	4.26	ENST00000289373.4	TMSB15A	thymosin beta 15a
chr3_+_62304712	4.09	ENST00000494481.1	C3orf14	chromosome 3 open reading frame 14
chr22_+_38597889	4.07	ENST00000338483.2 ENST00000538320.1 ENST00000538999.1 ENST00000441709.1	MAFF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr3_+_62304648	3.86	ENST00000462069.1 ENST00000232519.5 ENST00000465142.1	C3orf14	chromosome 3 open reading frame 14
chr3_+_158991025	3.86	ENST00000337808.6	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	18.5	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.1	13.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	9.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2	9.6	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	8.6	GO:0051219	phosphoprotein binding(GO:0051219)
0.1	8.0	GO:0016504	peptidase activator activity(GO:0016504)
0.1	7.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	6.7	GO:0051015	actin filament binding(GO:0051015)
0.3	5.8	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	5.5	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)

Showing 1 to 10 of 114 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	10.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	8.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.8	8.4	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
0.2	8.2	GO:0016504	peptidase activator activity(GO:0016504)
0.2	7.9	GO:0003785	actin monomer binding(GO:0003785)
0.7	6.7	GO:0019826	oxygen sensor activity(GO:0019826)
0.1	6.7	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	6.2	GO:0051015	actin filament binding(GO:0051015)
0.2	5.1	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	6.1	GO:0008859	exoribonuclease II activity(GO:0008859)
0.7	4.6	GO:0004126	cytidine deaminase activity(GO:0004126)
1.2	3.7	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.9	3.7	GO:0019976	interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1	2.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	2.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.1	2.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3	2.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	1.9	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	1.6	GO:0001784	phosphotyrosine binding(GO:0001784)

Showing 1 to 10 of 45 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	8.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	8.0	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	6.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	5.9	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	4.6	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.1	4.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	4.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	4.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.2	3.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly

Showing 1 to 10 of 50 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	15.6	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.6	11.8	GO:0071850	mitotic cell cycle arrest(GO:0071850)
1.2	9.6	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.3	9.0	GO:0042730	fibrinolysis(GO:0042730)
1.0	8.6	GO:1902412	regulation of mitotic cytokinesis(GO:1902412)
0.8	8.1	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.7	8.0	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.0	5.8	GO:0055064	chloride ion homeostasis(GO:0055064)
0.3	5.3	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.1	5.2	GO:0030574	collagen catabolic process(GO:0030574)

Showing 1 to 10 of 191 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	8.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	8.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	6.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	5.7	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	4.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	3.6	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	3.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	3.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.8	SIG CHEMOTAXIS	Genes related to chemotaxis

Showing 1 to 10 of 43 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	6.6	GO:0015030	Cajal body(GO:0015030)
0.2	4.3	GO:0000178	exosome (RNase complex)(GO:0000178)
0.4	3.5	GO:0070652	HAUS complex(GO:0070652)
0.0	2.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	2.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	2.4	GO:0034707	chloride channel complex(GO:0034707)
0.0	2.3	GO:0005643	nuclear pore(GO:0005643)
0.3	2.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.5	1.9	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)

Showing 1 to 10 of 33 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.3	GO:0015629	actin cytoskeleton(GO:0015629)
0.0	9.9	GO:0031012	extracellular matrix(GO:0031012)
0.6	8.2	GO:0005577	fibrinogen complex(GO:0005577)
0.6	8.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	7.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.2	7.2	GO:0005605	basal lamina(GO:0005605)
0.4	6.7	GO:0043020	NADPH oxidase complex(GO:0043020)
1.3	6.6	GO:0071148	TEAD-1-YAP complex(GO:0071148)
0.2	4.3	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	4.0	GO:0016460	myosin II complex(GO:0016460)

Showing 1 to 10 of 83 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	3.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	3.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	2.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	1.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.9	PID FOXO PATHWAY	FoxO family signaling

Showing 1 to 10 of 15 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	8.2	PID PLK1 PATHWAY	PLK1 signaling events
0.3	8.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	7.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	5.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	5.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	5.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	3.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	3.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 10 of 37 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	8.4	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
2.7	8.2	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1	8.2	GO:0030574	collagen catabolic process(GO:0030574)
0.2	7.1	GO:0042730	fibrinolysis(GO:0042730)
0.2	6.7	GO:0050667	homocysteine metabolic process(GO:0050667)
0.2	6.5	GO:0007567	parturition(GO:0007567)
0.3	6.1	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.2	6.1	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0	5.8	GO:0007015	actin filament organization(GO:0007015)
0.1	5.0	GO:0070936	protein K48-linked ubiquitination(GO:0070936)

Showing 1 to 10 of 179 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	3.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	2.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	2.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	1.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	1.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	1.1	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.1	0.9	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism

Showing 1 to 10 of 21 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	18.4	GO:0071148	TEAD-1-YAP complex(GO:0071148)
1.1	9.1	GO:0000235	astral microtubule(GO:0000235) aster(GO:0005818)
0.1	9.0	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	9.0	GO:0045177	apical part of cell(GO:0045177)
0.0	8.9	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.6	8.0	GO:0005577	fibrinogen complex(GO:0005577)
0.0	6.7	GO:0032587	ruffle membrane(GO:0032587)
0.1	6.6	GO:0072686	mitotic spindle(GO:0072686)
0.0	5.7	GO:0030018	Z disc(GO:0030018)
0.4	5.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Showing 1 to 10 of 83 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	17.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	8.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	7.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4	5.8	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.3	5.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	5.3	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.1	5.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	4.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.2	4.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	3.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling

Showing 1 to 10 of 43 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.7	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
2.0	6.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	4.9	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.7	4.6	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
1.2	3.7	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
0.5	3.7	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.0	3.5	GO:0051225	spindle assembly(GO:0051225)
0.3	2.8	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2	2.4	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1	2.3	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)

Showing 1 to 10 of 69 entries

Results for JUN

Z-value: 1.76

Motif logo

Transcription factors associated with JUN

Activity-expression correlation:

Activity profile of JUN motif

Sorted Z-values of JUN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category: