ISMARA results: KLF1

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ENCODE cell lines, expression (Ernst 2011)

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Results for KLF1

Z-value: 3.22

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Transcription factors associated with KLF1

Gene Symbol	Gene ID	Gene Info
KLF1 Ensembl NCBI GeneCards UniProt	ENSG00000105610.4	KLF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF1	hg19_v2_chr19_-_12997995_12998021	-0.46	7.0e-02	Click!

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr10_+_17272608	12.15	ENST00000421459.2	VIM	vimentin
chr10_+_47746929	11.48	ENST00000340243.6 ENST00000374277.5 ENST00000449464.2 ENST00000538825.1 ENST00000335083.5	ANXA8L2 AL603965.1	annexin A8-like 2 Protein LOC100996760
chr10_-_47173994	11.39	ENST00000414655.2 ENST00000545298.1 ENST00000359178.4 ENST00000358140.4 ENST00000503031.1	ANXA8L1 LINC00842	annexin A8-like 1 long intergenic non-protein coding RNA 842
chr1_-_151965048	9.26	ENST00000368809.1	S100A10	S100 calcium binding protein A10
chr17_-_1619535	8.48	ENST00000573075.1 ENST00000574306.1	MIR22HG	MIR22 host gene (non-protein coding)
chr2_+_173292301	8.27	ENST00000264106.6 ENST00000375221.2 ENST00000343713.4	ITGA6	integrin, alpha 6
chr22_+_38071615	8.18	ENST00000215909.5	LGALS1	lectin, galactoside-binding, soluble, 1
chr17_-_1619491	8.11	ENST00000570416.1 ENST00000575626.1 ENST00000610106.1 ENST00000608198.1 ENST00000609442.1 ENST00000334146.3 ENST00000576489.1 ENST00000608245.1 ENST00000609398.1 ENST00000608913.1 ENST00000574016.1 ENST00000571091.1 ENST00000573127.1 ENST00000609990.1 ENST00000576749.1	MIR22HG	MIR22 host gene (non-protein coding)
chr19_-_51522955	7.78	ENST00000358789.3	KLK10	kallikrein-related peptidase 10
chr1_-_153508460	7.69	ENST00000462776.2	S100A6	S100 calcium binding protein A6

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.8	GO:0000052	citrulline metabolic process(GO:0000052)
0.9	6.5	GO:0070294	renal sodium ion absorption(GO:0070294)
0.5	5.3	GO:1904417	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.1	3.8	GO:0003197	endocardial cushion development(GO:0003197)
0.4	3.5	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.7	2.9	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1	2.9	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	2.9	GO:0046324	regulation of glucose import(GO:0046324)
0.1	2.5	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.2	2.3	GO:1904778	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)

Showing 1 to 10 of 392 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	2.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.9	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.8	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	2.8	GO:0042169	SH2 domain binding(GO:0042169)
0.3	2.7	GO:0034711	inhibin binding(GO:0034711)
0.0	1.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	1.4	GO:0035614	snRNA stem-loop binding(GO:0035614)
0.1	1.4	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	1.3	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.1	1.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	1.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.3	1.1	GO:0038025	glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)

Showing 1 to 10 of 73 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	3.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	2.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.8	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	2.8	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1	2.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	2.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	2.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	1.9	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	1.8	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	2.2	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.1	1.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	1.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	1.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.7	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.6	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.5	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 22 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.9	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	4.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	4.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	3.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	2.8	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	2.5	GO:0005801	cis-Golgi network(GO:0005801)
0.2	2.3	GO:0008091	spectrin(GO:0008091)
0.0	2.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	2.0	GO:0005581	collagen trimer(GO:0005581)
0.1	1.9	GO:0045495	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

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Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	2.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	1.6	GO:0005814	centriole(GO:0005814)
0.0	1.4	GO:0032420	stereocilium(GO:0032420)
0.0	1.3	GO:0005801	cis-Golgi network(GO:0005801)
0.2	1.0	GO:0033263	CORVET complex(GO:0033263)
0.0	1.0	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1	0.9	GO:0071203	WASH complex(GO:0071203)
0.0	0.9	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.9	GO:0042629	mast cell granule(GO:0042629)

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	44.7	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.5	36.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	33.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.4	27.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	27.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.5	25.9	PID ATM PATHWAY	ATM pathway
1.1	24.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	24.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.9	22.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4	20.0	PID IFNG PATHWAY	IFN-gamma pathway

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.8	GO:0016403	dimethylargininase activity(GO:0016403)
0.0	3.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	3.1	GO:0047134	protein-disulfide reductase activity(GO:0047134)
0.5	1.5	GO:0045127	N-acetylglucosamine kinase activity(GO:0045127)
0.0	1.4	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0	1.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	1.0	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.9	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.9	GO:0008276	protein methyltransferase activity(GO:0008276)
0.3	0.8	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)

Showing 1 to 10 of 40 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	2.8	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	1.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	1.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.0	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.9	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.8	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.6	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.2	0.5	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC

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Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	32.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	30.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	22.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	18.1	PID NOTCH PATHWAY	Notch signaling pathway
0.4	17.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	9.3	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	8.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	7.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	6.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.2	PID NECTIN PATHWAY	Nectin adhesion pathway
1.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
1.2	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.9	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.6	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	45.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	40.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	37.3	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.0	29.6	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.7	26.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
1.0	25.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.7	25.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.5	23.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
1.4	23.0	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6	22.9	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery

Showing 1 to 10 of 218 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.0	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	1.0	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.9	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.7	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.7	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.7	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.6	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

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Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.5	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.3	1.9	GO:0016554	cytidine to uridine editing(GO:0016554)
0.4	1.8	GO:0072301	regulation of metanephric glomerular mesangial cell proliferation(GO:0072301)
0.1	1.4	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	1.4	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.4	1.3	GO:0046619	optic placode formation involved in camera-type eye formation(GO:0046619)
0.4	1.2	GO:0060061	Spemann organizer formation(GO:0060061)
0.1	1.1	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	1.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.3	1.0	GO:0021678	fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)

Showing 1 to 10 of 94 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.8	GO:0006527	arginine catabolic process(GO:0006527)
0.2	3.1	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	3.1	GO:0045454	cell redox homeostasis(GO:0045454)
0.1	1.8	GO:0031643	positive regulation of myelination(GO:0031643)
0.4	1.5	GO:0006051	mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.3	1.4	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	1.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	1.1	GO:0071470	cellular response to osmotic stress(GO:0071470)
0.0	1.1	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.2	1.0	GO:0002254	regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)

Showing 1 to 10 of 58 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	23.9	GO:0035878	nail development(GO:0035878)
0.4	17.4	GO:0060216	definitive hemopoiesis(GO:0060216)
0.7	15.9	GO:0031581	hemidesmosome assembly(GO:0031581)
1.0	11.5	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
1.0	11.5	GO:0002934	desmosome organization(GO:0002934)
0.8	11.5	GO:0090168	Golgi reassembly(GO:0090168)
1.7	10.3	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.1	9.7	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.3	9.3	GO:0051290	protein heterotetramerization(GO:0051290)
1.1	8.8	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)

Showing 1 to 10 of 164 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.5	GO:0043203	axon hillock(GO:0043203)
0.6	1.9	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	1.8	GO:0031901	early endosome membrane(GO:0031901)
0.0	1.7	GO:0005796	Golgi lumen(GO:0005796)
0.2	1.2	GO:1990393	3M complex(GO:1990393)
0.2	1.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1	0.7	GO:0000815	ESCRT III complex(GO:0000815)
0.1	0.6	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1	0.6	GO:0030061	mitochondrial crista(GO:0030061)

Showing 1 to 10 of 41 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	262.9	GO:0005654	nucleoplasm(GO:0005654)
0.2	57.5	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.5	44.6	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	38.4	GO:0005667	transcription factor complex(GO:0005667)
1.5	35.1	GO:0005861	troponin complex(GO:0005861)
0.3	34.1	GO:0016605	PML body(GO:0016605)
1.3	27.9	GO:0042627	chylomicron(GO:0042627)
0.3	26.3	GO:0016363	nuclear matrix(GO:0016363)
0.3	25.8	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.3	24.5	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Showing 1 to 10 of 453 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	5.8	GO:0016403	dimethylargininase activity(GO:0016403)
0.2	4.0	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.1	3.6	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.1	2.9	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.3	2.8	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.3	2.7	GO:0042731	PH domain binding(GO:0042731)
0.0	2.7	GO:0008201	heparin binding(GO:0008201)
0.3	2.4	GO:0047134	protein-disulfide reductase activity(GO:0047134)
0.2	2.3	GO:0038132	neuregulin binding(GO:0038132)
0.0	2.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)

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Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:0005796	Golgi lumen(GO:0005796)
0.9	2.8	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3	2.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	1.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.3	GO:0036064	ciliary basal body(GO:0036064)
0.0	1.2	GO:0005685	U1 snRNP(GO:0005685)
0.0	1.1	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1	1.0	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	1.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.2	0.9	GO:0032449	CBM complex(GO:0032449)

Showing 1 to 10 of 38 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	42.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.8	33.5	GO:0006270	DNA replication initiation(GO:0006270)
0.4	30.2	GO:0070125	mitochondrial translational elongation(GO:0070125)
3.3	30.1	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.1	27.2	GO:0006337	nucleosome disassembly(GO:0006337)
0.5	26.9	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
3.9	23.4	GO:0030421	defecation(GO:0030421)
1.4	22.8	GO:0009113	purine nucleobase biosynthetic process(GO:0009113)
1.2	22.5	GO:0034349	glial cell apoptotic process(GO:0034349)
1.6	20.3	GO:0021894	cerebral cortex GABAergic interneuron development(GO:0021894)

Showing 1 to 10 of 1,439 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	78.5	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.4	74.1	GO:0042393	histone binding(GO:0042393)
0.1	65.8	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1	60.8	GO:0003677	DNA binding(GO:0003677)
2.6	36.1	GO:0031014	troponin T binding(GO:0031014)
0.6	33.8	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.2	30.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	26.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.6	26.2	GO:0031492	nucleosomal DNA binding(GO:0031492)
3.0	24.0	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)

Showing 1 to 10 of 791 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.4	ST G ALPHA S PATHWAY	G alpha s Pathway
1.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
1.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
1.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.9	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.6	ST ADRENERGIC	Adrenergic Pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.5	GO:0044325	ion channel binding(GO:0044325)
0.1	19.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	19.2	GO:0038132	neuregulin binding(GO:0038132)
0.2	19.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	16.2	GO:0005198	structural molecule activity(GO:0005198)
0.3	15.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.7	13.3	GO:0044548	S100 protein binding(GO:0044548)
2.0	12.2	GO:1990254	keratin filament binding(GO:1990254)
0.3	12.0	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.6	10.7	GO:0038191	neuropilin binding(GO:0038191)

Showing 1 to 10 of 106 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	21.5	GO:0031012	extracellular matrix(GO:0031012)
7.1	21.3	GO:0034676	integrin alpha6-beta4 complex(GO:0034676)
0.2	20.6	GO:0005882	intermediate filament(GO:0005882)
0.8	17.0	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.5	16.5	GO:0030057	desmosome(GO:0030057)
0.0	15.6	GO:0005615	extracellular space(GO:0005615)
1.4	11.6	GO:0005610	laminin-5 complex(GO:0005610)
0.1	10.9	GO:0034707	chloride channel complex(GO:0034707)
0.1	9.3	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	9.3	GO:0019897	extrinsic component of plasma membrane(GO:0019897)

Showing 1 to 10 of 86 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	1.8	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.1	1.5	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	1.4	GO:0001848	complement binding(GO:0001848)
0.2	1.3	GO:0050692	DBD domain binding(GO:0050692)
0.0	1.3	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	1.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	1.1	GO:0051525	NFAT protein binding(GO:0051525)
0.1	1.1	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	1.1	GO:0005540	hyaluronic acid binding(GO:0005540)

Showing 1 to 10 of 80 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	13.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	12.8	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.4	11.5	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.5	8.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	8.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	7.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	5.3	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	5.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	5.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	4.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	3.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	3.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	2.0	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	2.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	1.8	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	1.8	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.3	SIG CHEMOTAXIS	Genes related to chemotaxis

Showing 1 to 10 of 47 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0048627	myoblast development(GO:0048627)
0.1	2.8	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.0	2.1	GO:0030879	mammary gland development(GO:0030879)
0.5	1.6	GO:0045014	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.2	1.6	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	1.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	1.3	GO:0006637	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.3	1.1	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.2	1.1	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.0	1.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923)

Showing 1 to 10 of 117 entries

Results for KLF1

Z-value: 3.22

Motif logo

Transcription factors associated with KLF1

Activity-expression correlation:

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category: