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ENCODE cell lines, expression (Ernst 2011)
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Results for KLF16_SP2
Z-value: 3.56
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg19_v2_chr17_+_45973516_45973618 | 0.40 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_43583079 | 12.75 |
ENST00000216129.6 |
TTLL12 |
tubulin tyrosine ligase-like family, member 12 |
| chr19_-_55658650 | 12.55 |
ENST00000589226.1 |
TNNT1 |
troponin T type 1 (skeletal, slow) |
| chr17_-_79008373 | 11.87 |
ENST00000577066.1 ENST00000573167.1 |
BAIAP2-AS1 |
BAIAP2 antisense RNA 1 (head to head) |
| chr16_+_23847339 | 11.38 |
ENST00000303531.7 |
PRKCB |
protein kinase C, beta |
| chr19_-_55658687 | 10.75 |
ENST00000593046.1 |
TNNT1 |
troponin T type 1 (skeletal, slow) |
| chr16_+_29817841 | 10.31 |
ENST00000322945.6 ENST00000562337.1 ENST00000566906.2 ENST00000563402.1 ENST00000219782.6 |
MAZ |
MYC-associated zinc finger protein (purine-binding transcription factor) |
| chr15_+_80445113 | 10.24 |
ENST00000407106.1 ENST00000261755.5 |
FAH |
fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| chr19_-_55866061 | 9.48 |
ENST00000588572.2 ENST00000593184.1 ENST00000589467.1 |
COX6B2 |
cytochrome c oxidase subunit VIb polypeptide 2 (testis) |
| chr15_+_80445232 | 8.73 |
ENST00000561421.1 |
FAH |
fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| chrX_-_151903101 | 8.52 |
ENST00000393900.3 |
MAGEA12 |
melanoma antigen family A, 12 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 44.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.5 | 36.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 33.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 27.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 27.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 25.9 | PID ATM PATHWAY | ATM pathway |
| 1.1 | 24.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 24.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.9 | 22.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.4 | 20.0 | PID IFNG PATHWAY | IFN-gamma pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 45.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 40.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 37.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 29.6 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.7 | 26.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 1.0 | 25.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.7 | 25.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.5 | 23.5 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.4 | 23.0 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.6 | 22.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 262.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 57.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 44.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 38.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.5 | 35.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.3 | 34.1 | GO:0016605 | PML body(GO:0016605) |
| 1.3 | 27.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.3 | 26.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.3 | 25.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.3 | 24.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 42.1 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.8 | 33.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 30.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 3.3 | 30.1 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 1.1 | 27.2 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.5 | 26.9 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 3.9 | 23.4 | GO:0030421 | defecation(GO:0030421) |
| 1.4 | 22.8 | GO:0009113 | purine nucleobase biosynthetic process(GO:0009113) |
| 1.2 | 22.5 | GO:0034349 | glial cell apoptotic process(GO:0034349) |
| 1.6 | 20.3 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 78.5 | GO:0000976 | transcription regulatory region sequence-specific DNA binding(GO:0000976) |
| 0.4 | 74.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 65.8 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 60.8 | GO:0003677 | DNA binding(GO:0003677) |
| 2.6 | 36.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.6 | 33.8 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.2 | 30.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 26.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 26.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 3.0 | 24.0 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |