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ENCODE cell lines, expression (Ernst 2011)
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Results for MAFK
Z-value: 1.31
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Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg19_v2_chr7_+_1570322_1570360 | 0.34 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_69962185 | 7.92 |
ENST00000305231.7 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr4_+_69962212 | 7.58 |
ENST00000508661.1 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr4_-_110723134 | 3.87 |
ENST00000510800.1 ENST00000512148.1 |
CFI |
complement factor I |
| chr17_-_64216748 | 3.63 |
ENST00000585162.1 |
APOH |
apolipoprotein H (beta-2-glycoprotein I) |
| chr3_+_133465228 | 3.59 |
ENST00000482271.1 ENST00000264998.3 |
TF |
transferrin |
| chr9_+_103947311 | 3.19 |
ENST00000395056.2 |
LPPR1 |
Lipid phosphate phosphatase-related protein type 1 |
| chr4_+_69681710 | 3.14 |
ENST00000265403.7 ENST00000458688.2 |
UGT2B10 |
UDP glucuronosyltransferase 2 family, polypeptide B10 |
| chr11_+_22696314 | 3.03 |
ENST00000532398.1 ENST00000433790.1 |
GAS2 |
growth arrest-specific 2 |
| chr2_+_47596287 | 3.00 |
ENST00000263735.4 |
EPCAM |
epithelial cell adhesion molecule |
| chr4_-_110723194 | 2.85 |
ENST00000394635.3 |
CFI |
complement factor I |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.5 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 1.6 | 11.5 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.1 | 8.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 6.3 | GO:0034197 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 4.7 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 4.3 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.5 | 4.1 | GO:0046149 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.6 | 3.6 | GO:0097460 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.0 | 3.5 | GO:0070268 | cornification(GO:0070268) |
| 1.0 | 3.0 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 23.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.3 | 8.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 5.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 5.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 5.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.6 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.1 | 3.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 2.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.8 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 8.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 7.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 6.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 3.7 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 3.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 2.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 2.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.9 | 11.1 | GO:0018636 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.1 | 8.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 1.1 | 5.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 4.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 4.1 | GO:0019862 | IgA binding(GO:0019862) |
| 1.2 | 3.6 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.1 | 3.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 2.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.3 | 2.8 | GO:0070324 | thyroid hormone binding(GO:0070324) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 1.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |