Project
ENCODE cell lines, expression (Ernst 2011)
Navigation
Downloads
Results for MEF2C
Z-value: 1.96
Motif logo
Transcription factors associated with MEF2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2C | hg19_v2_chr5_-_88119580_88119605 | 0.15 | 5.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2C
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_143226979 | 15.36 |
ENST00000514525.1 |
INPP4B |
inositol polyphosphate-4-phosphatase, type II, 105kDa |
| chr4_-_143227088 | 11.00 |
ENST00000511838.1 |
INPP4B |
inositol polyphosphate-4-phosphatase, type II, 105kDa |
| chr4_+_169418195 | 9.44 |
ENST00000261509.6 ENST00000335742.7 |
PALLD |
palladin, cytoskeletal associated protein |
| chr1_-_201391149 | 9.14 |
ENST00000555948.1 ENST00000556362.1 |
TNNI1 |
troponin I type 1 (skeletal, slow) |
| chr4_+_169418255 | 6.97 |
ENST00000505667.1 ENST00000511948.1 |
PALLD |
palladin, cytoskeletal associated protein |
| chr2_-_151344172 | 6.95 |
ENST00000375734.2 ENST00000263895.4 ENST00000454202.1 |
RND3 |
Rho family GTPase 3 |
| chr8_-_49834299 | 6.52 |
ENST00000396822.1 |
SNAI2 |
snail family zinc finger 2 |
| chr3_+_8543393 | 6.32 |
ENST00000157600.3 ENST00000415597.1 ENST00000535732.1 |
LMCD1 |
LIM and cysteine-rich domains 1 |
| chr8_-_49833978 | 6.13 |
ENST00000020945.1 |
SNAI2 |
snail family zinc finger 2 |
| chr10_-_75410771 | 6.11 |
ENST00000372873.4 |
SYNPO2L |
synaptopodin 2-like |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 9.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 8.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 3.0 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 2.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 2.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 32.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 24.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 21.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 16.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 13.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 12.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 6.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 4.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 1.1 | 4.4 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 3.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.6 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.6 | 16.5 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.7 | 16.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.9 | 13.6 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.1 | 12.9 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 4.2 | 12.7 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.1 | 11.3 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.2 | 9.6 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 8.2 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 1.9 | 7.8 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 32.3 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.8 | 17.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 17.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 17.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 14.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 12.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 8.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 8.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.9 | 6.5 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.5 | 5.7 | GO:0031014 | troponin T binding(GO:0031014) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 32.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.4 | 28.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.9 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 3.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 2.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 2.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 2.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 2.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |