Project
ENCODE cell lines, expression (Ernst 2011)
Navigation
Downloads
Results for MEF2D_MEF2A
Z-value: 2.05
Motif logo
Transcription factors associated with MEF2D_MEF2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2A | hg19_v2_chr15_+_100106155_100106243 | 0.58 | 1.9e-02 | Click! |
| MEF2D | hg19_v2_chr1_-_156460391_156460417, hg19_v2_chr1_-_156470556_156470643 | 0.19 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2D_MEF2A
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_201391149 | 12.28 |
ENST00000555948.1 ENST00000556362.1 |
TNNI1 |
troponin I type 1 (skeletal, slow) |
| chr5_-_111091948 | 9.25 |
ENST00000447165.2 |
NREP |
neuronal regeneration related protein |
| chr2_-_211168332 | 8.84 |
ENST00000341685.4 |
MYL1 |
myosin, light chain 1, alkali; skeletal, fast |
| chr3_+_138067521 | 8.26 |
ENST00000494949.1 |
MRAS |
muscle RAS oncogene homolog |
| chr10_-_75415825 | 7.41 |
ENST00000394810.2 |
SYNPO2L |
synaptopodin 2-like |
| chr5_+_53751445 | 7.40 |
ENST00000302005.1 |
HSPB3 |
heat shock 27kDa protein 3 |
| chr3_-_52486841 | 7.27 |
ENST00000496590.1 |
TNNC1 |
troponin C type 1 (slow) |
| chrX_-_21776281 | 7.24 |
ENST00000379494.3 |
SMPX |
small muscle protein, X-linked |
| chr2_-_190044480 | 5.95 |
ENST00000374866.3 |
COL5A2 |
collagen, type V, alpha 2 |
| chr3_+_138067314 | 5.54 |
ENST00000423968.2 |
MRAS |
muscle RAS oncogene homolog |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.4 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 19.6 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 1.1 | 15.9 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.2 | 12.0 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 2.6 | 10.3 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.1 | 7.0 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 1.5 | 5.9 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 0.2 | 5.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.4 | 5.3 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.0 | 5.2 | GO:0006986 | response to unfolded protein(GO:0006986) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 24.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 22.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.6 | 21.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 1.7 | 10.3 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.3 | 8.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 1.1 | 6.8 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 2.0 | 5.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 5.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.3 | 5.1 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.5 | 5.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 48.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 10.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 4.7 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 4.3 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.3 | 4.1 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 3.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 3.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 2.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.2 | 18.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.5 | 18.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 1.3 | 14.5 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.5 | 10.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 10.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 9.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 6.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 4.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.8 | 4.1 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 6.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 4.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 3.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 2.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 2.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |