ISMARA results: MXI1_MYC

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ENCODE cell lines, expression (Ernst 2011)

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Results for MXI1_MYC_MYCN

Z-value: 2.85

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Transcription factors associated with MXI1_MYC_MYCN

Gene Symbol	Gene ID	Gene Info
MXI1 Ensembl NCBI GeneCards UniProt	ENSG00000119950.16	MXI1
MYC Ensembl NCBI GeneCards UniProt	ENSG00000136997.10	MYC
MYCN Ensembl NCBI GeneCards UniProt	ENSG00000134323.10	MYCN

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYC	hg19_v2_chr8_+_128748466_128748487, hg19_v2_chr8_+_128748308_128748330	0.71	2.1e-03	Click!
MXI1	hg19_v2_chr10_+_111967345_111967442, hg19_v2_chr10_+_111985713_111985774	-0.25	3.5e-01	Click!
MYCN	hg19_v2_chr2_+_16080659_16080686	0.03	9.1e-01	Click!

Activity profile of MXI1_MYC_MYCN motif

Sorted Z-values of MXI1_MYC_MYCN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MXI1_MYC_MYCN

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_226658	6.91	ENST00000320868.5 ENST00000397797.1	HBA1	hemoglobin, alpha 1
chr19_-_41903161	6.35	ENST00000602129.1 ENST00000593771.1 ENST00000596905.1 ENST00000221233.4	EXOSC5	exosome component 5
chr17_+_40440481	6.02	ENST00000590726.2 ENST00000452307.2 ENST00000444283.1 ENST00000588868.1	STAT5A	signal transducer and activator of transcription 5A
chr4_-_57301748	5.94	ENST00000264220.2	PPAT	phosphoribosyl pyrophosphate amidotransferase
chr8_+_142402089	5.23	ENST00000521578.1 ENST00000520105.1 ENST00000523147.1	PTP4A3	protein tyrosine phosphatase type IVA, member 3
chr1_+_12123414	5.05	ENST00000263932.2	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr14_-_20923195	4.87	ENST00000206542.4	OSGEP	O-sialoglycoprotein endopeptidase
chr6_-_43197189	4.85	ENST00000509253.1 ENST00000393987.2 ENST00000230431.6	DNPH1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr2_-_10588630	4.74	ENST00000234111.4	ODC1	ornithine decarboxylase 1
chr16_+_222846	4.63	ENST00000251595.6 ENST00000397806.1	HBA2	hemoglobin, alpha 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	44.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	13.0	PID E2F PATHWAY	E2F transcription factor network
0.2	11.9	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.5	10.1	ST STAT3 PATHWAY	STAT3 Pathway
0.1	9.9	PID LKB1 PATHWAY	LKB1 signaling events
0.1	9.6	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.2	9.5	PID AURORA A PATHWAY	Aurora A signaling
0.4	9.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	8.2	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	7.9	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network

Showing 1 to 10 of 92 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	19.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3	18.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	15.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	12.4	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.5	12.1	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.3	11.0	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.3	10.8	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.6	9.5	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.5	8.8	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	8.8	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing

Showing 1 to 10 of 159 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	19.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.3	13.5	GO:0006270	DNA replication initiation(GO:0006270)
0.3	12.5	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.7	10.8	GO:0015671	oxygen transport(GO:0015671)
1.0	9.7	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.1	9.6	GO:0006364	rRNA processing(GO:0006364)
0.2	9.4	GO:0006400	tRNA modification(GO:0006400)
2.3	9.3	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.8	9.2	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
1.1	8.4	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)

Showing 1 to 10 of 757 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	10.8	GO:0005344	oxygen transporter activity(GO:0005344)
0.2	10.8	GO:0016831	carboxy-lyase activity(GO:0016831)
0.2	10.7	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	10.7	GO:0003924	GTPase activity(GO:0003924)
0.3	10.2	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.3	10.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.6	9.6	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.5	9.4	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.3	9.3	GO:0051059	NF-kappaB binding(GO:0051059)
0.2	9.3	GO:0008536	Ran GTPase binding(GO:0008536)

Showing 1 to 10 of 524 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	46.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	33.3	GO:0005739	mitochondrion(GO:0005739)
0.6	14.7	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.2	14.2	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	14.2	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	13.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.3	13.1	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2	10.9	GO:0015030	Cajal body(GO:0015030)
0.5	9.9	GO:0034709	methylosome(GO:0034709)
0.1	9.8	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 302 entries

Results for MXI1_MYC_MYCN

Z-value: 2.85

Motif logo

Transcription factors associated with MXI1_MYC_MYCN

Activity-expression correlation:

Activity profile of MXI1_MYC_MYCN motif

Sorted Z-values of MXI1_MYC_MYCN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MXI1_MYC_MYCN

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category: