ISMARA results: MYB

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ENCODE cell lines, expression (Ernst 2011)

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Results for MYB

Z-value: 2.03

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Transcription factors associated with MYB

Gene Symbol	Gene ID	Gene Info
MYB Ensembl NCBI GeneCards UniProt	ENSG00000118513.14	MYB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYB	hg19_v2_chr6_+_135502501_135502652	0.95	2.4e-08	Click!

Activity profile of MYB motif

Sorted Z-values of MYB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MYB

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Promoter	Score	Transcript	Gene	Gene Info
chr1_-_85155939	3.50	ENST00000603677.1	SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein
chr11_-_67888671	3.36	ENST00000265689.4	CHKA	choline kinase alpha
chrX_+_37545012	3.25	ENST00000378616.3	XK	X-linked Kx blood group (McLeod syndrome)
chr1_-_85156216	2.86	ENST00000342203.3 ENST00000370612.4	SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein
chr14_+_29236269	2.77	ENST00000313071.4	FOXG1	forkhead box G1
chrX_-_151903101	2.69	ENST00000393900.3	MAGEA12	melanoma antigen family A, 12
chr1_-_114355083	2.63	ENST00000261441.5	RSBN1	round spermatid basic protein 1
chr17_+_45286387	2.59	ENST00000572316.1 ENST00000354968.1 ENST00000576874.1 ENST00000536623.2	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chr2_-_111435610	2.53	ENST00000447014.1 ENST00000420328.1 ENST00000535254.1 ENST00000409311.1 ENST00000302759.6	BUB1	BUB1 mitotic checkpoint serine/threonine kinase
chr17_+_45286706	2.37	ENST00000393450.1 ENST00000572303.1	MYL4	myosin, light chain 4, alkali; atrial, embryonic

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	GO:0005681	spliceosomal complex(GO:0005681)
0.0	3.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	3.2	GO:0035371	microtubule plus-end(GO:0035371)
0.0	2.8	GO:0045171	intercellular bridge(GO:0045171)
0.7	2.7	GO:0032301	MutSalpha complex(GO:0032301)
0.0	2.6	GO:0031672	A band(GO:0031672)
0.0	2.6	GO:0000776	kinetochore(GO:0000776)
0.0	2.4	GO:0005801	cis-Golgi network(GO:0005801)
0.1	2.3	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	2.0	GO:0033588	Elongator holoenzyme complex(GO:0033588)

Showing 1 to 10 of 91 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.9	PID PLK1 PATHWAY	PLK1 signaling events
0.1	6.9	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	4.7	PID E2F PATHWAY	E2F transcription factor network
0.1	4.2	PID AURORA B PATHWAY	Aurora B signaling
0.1	4.0	PID MYC PATHWAY	C-MYC pathway
0.0	3.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	3.5	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	3.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	3.2	PID ATM PATHWAY	ATM pathway
0.1	3.0	PID TRAIL PATHWAY	TRAIL signaling pathway

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.4	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.7	2.7	GO:0032143	single thymine insertion binding(GO:0032143)
0.7	2.6	GO:0032038	myosin II heavy chain binding(GO:0032038)
0.3	2.4	GO:0019237	centromeric DNA binding(GO:0019237)
0.2	2.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.9	GO:0008536	Ran GTPase binding(GO:0008536)
0.6	1.8	GO:0008798	beta-aspartyl-peptidase activity(GO:0008798)
0.2	1.8	GO:0030274	LIM domain binding(GO:0030274)
0.2	1.7	GO:0001849	complement component C1q binding(GO:0001849)
0.1	1.7	GO:0031996	thioesterase binding(GO:0031996)

Showing 1 to 10 of 132 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	2.7	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	1.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	1.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	1.1	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.7	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.4	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Showing 1 to 10 of 15 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1	2.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	2.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	2.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	1.1	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.8	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling

Showing 1 to 10 of 15 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	8.6	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.6	5.6	GO:0019695	choline metabolic process(GO:0019695)
0.3	5.2	GO:0016180	snRNA processing(GO:0016180)
0.1	5.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.1	5.0	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2	4.4	GO:0034453	microtubule anchoring(GO:0034453)
0.1	4.1	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2	4.0	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	4.0	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.9	3.6	GO:0090579	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)

Showing 1 to 10 of 282 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	4.5	GO:0001849	complement component C1q binding(GO:0001849)
0.1	2.7	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2	2.6	GO:0003680	AT DNA binding(GO:0003680)
0.2	2.4	GO:0031996	thioesterase binding(GO:0031996)
0.0	2.1	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	1.8	GO:0070888	E-box binding(GO:0070888)
0.2	1.2	GO:0052656	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0	1.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.3	1.0	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.1	1.0	GO:0050786	RAGE receptor binding(GO:0050786)

Showing 1 to 10 of 58 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	10.2	GO:0034451	centriolar satellite(GO:0034451)
0.4	8.2	GO:0033202	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	7.2	GO:0016607	nuclear speck(GO:0016607)
0.1	6.8	GO:0031970	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.7	6.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	5.4	GO:0031672	A band(GO:0031672)
0.6	5.2	GO:0032039	integrator complex(GO:0032039)
0.2	4.8	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	3.8	GO:0000922	spindle pole(GO:0000922)
0.2	2.9	GO:0005642	annulate lamellae(GO:0005642)

Showing 1 to 10 of 140 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	PID AURORA B PATHWAY	Aurora B signaling
0.1	3.3	PID PLK1 PATHWAY	PLK1 signaling events
0.0	3.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	2.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	1.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.7	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	1.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	1.0	PID ILK PATHWAY	Integrin-linked kinase signaling

Showing 1 to 10 of 16 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.1	3.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	3.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4	3.0	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.2	2.4	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	2.3	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.1	2.1	GO:0006825	copper ion transport(GO:0006825)
0.0	2.1	GO:0021915	neural tube development(GO:0021915)
0.1	2.0	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.2	1.8	GO:0006528	asparagine metabolic process(GO:0006528)

Showing 1 to 10 of 197 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.3	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	7.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	5.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	4.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	4.3	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1	4.0	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.1	3.9	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.1	3.6	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	3.5	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	3.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.2	4.5	REACTOME KINESINS	Genes involved in Kinesins
0.0	3.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	2.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	2.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	1.9	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	1.8	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	1.7	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	1.2	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	1.1	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

Showing 1 to 10 of 35 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0035580	specific granule lumen(GO:0035580)
0.2	2.8	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	2.5	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	1.8	GO:0070469	respiratory chain(GO:0070469)
0.3	1.3	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	1.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.4	1.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.9	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	0.8	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 40 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	4.5	GO:0052199	negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0	3.3	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.2	2.8	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6	2.6	GO:0003185	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0	2.4	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.2	1.8	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.4	1.3	GO:1905154	negative regulation of membrane invagination(GO:1905154)
0.2	1.2	GO:0009098	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2	1.2	GO:2000546	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.3	1.1	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.0	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.9	5.6	GO:0004103	choline kinase activity(GO:0004103)
1.2	5.0	GO:0032038	myosin II heavy chain binding(GO:0032038)
1.0	3.9	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.6	3.6	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	3.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	3.5	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	3.4	GO:0042393	histone binding(GO:0042393)
0.7	2.9	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	2.9	GO:0035064	methylated histone binding(GO:0035064)

Showing 1 to 10 of 187 entries

Results for MYB

Z-value: 2.03

Motif logo

Transcription factors associated with MYB

Activity-expression correlation:

Activity profile of MYB motif

Sorted Z-values of MYB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MYB

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category: