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ENCODE cell lines, expression (Ernst 2011)
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Results for MYOD1
Z-value: 1.98
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Transcription factors associated with MYOD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOD1 | hg19_v2_chr11_+_17741111_17741124 | 0.93 | 1.1e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYOD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_175629135 | 9.24 |
ENST00000409542.1 ENST00000409219.1 |
CHRNA1 |
cholinergic receptor, nicotinic, alpha 1 (muscle) |
| chr1_-_201346761 | 6.65 |
ENST00000455702.1 ENST00000422165.1 ENST00000367318.5 ENST00000367320.2 ENST00000438742.1 ENST00000412633.1 ENST00000458432.2 ENST00000421663.2 ENST00000367322.1 ENST00000509001.1 |
TNNT2 |
troponin T type 2 (cardiac) |
| chr16_+_30387141 | 6.57 |
ENST00000566955.1 |
MYLPF |
myosin light chain, phosphorylatable, fast skeletal muscle |
| chr2_-_152590946 | 5.72 |
ENST00000172853.10 |
NEB |
nebulin |
| chr16_+_30383613 | 5.58 |
ENST00000568749.1 |
MYLPF |
myosin light chain, phosphorylatable, fast skeletal muscle |
| chr16_+_30386098 | 5.11 |
ENST00000322861.7 |
MYLPF |
myosin light chain, phosphorylatable, fast skeletal muscle |
| chr2_-_175629164 | 4.86 |
ENST00000409323.1 ENST00000261007.5 ENST00000348749.5 |
CHRNA1 |
cholinergic receptor, nicotinic, alpha 1 (muscle) |
| chr1_-_201391149 | 4.73 |
ENST00000555948.1 ENST00000556362.1 |
TNNI1 |
troponin I type 1 (skeletal, slow) |
| chr9_-_35689900 | 4.67 |
ENST00000378300.5 ENST00000329305.2 ENST00000360958.2 |
TPM2 |
tropomyosin 2 (beta) |
| chr15_-_35088340 | 4.60 |
ENST00000290378.4 |
ACTC1 |
actin, alpha, cardiac muscle 1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 13.0 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 5.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 4.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 4.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 2.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.6 | 20.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.3 | 14.8 | GO:0031672 | A band(GO:0031672) |
| 0.6 | 13.7 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.6 | 11.6 | GO:0005861 | troponin complex(GO:0005861) |
| 1.8 | 10.6 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.5 | 10.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.8 | 9.8 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
| 0.5 | 5.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.0 | 5.1 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 50.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.8 | 13.7 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 4.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 3.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.1 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.3 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 15.2 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 1.8 | 14.5 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 2.7 | 10.6 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 3.3 | 9.8 | GO:1900073 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
| 2.2 | 8.9 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.5 | 6.9 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 1.0 | 6.8 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.7 | 5.8 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 5.0 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 45.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.6 | 13.7 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 1.1 | 12.6 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.5 | 9.5 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 1.9 | 7.7 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.6 | 5.5 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 4.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 4.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 4.7 | GO:0016887 | ATPase activity(GO:0016887) |
| 1.5 | 4.5 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |