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ENCODE cell lines, expression (Ernst 2011)
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Results for NFATC2_NFATC3
Z-value: 2.16
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC3 | hg19_v2_chr16_+_68119247_68119293 | -0.64 | 7.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_190044480 | 8.41 |
ENST00000374866.3 |
COL5A2 |
collagen, type V, alpha 2 |
| chr9_-_35691017 | 7.72 |
ENST00000378292.3 |
TPM2 |
tropomyosin 2 (beta) |
| chr1_+_86046433 | 7.15 |
ENST00000451137.2 |
CYR61 |
cysteine-rich, angiogenic inducer, 61 |
| chr14_-_92413353 | 7.07 |
ENST00000556154.1 |
FBLN5 |
fibulin 5 |
| chr12_-_91573132 | 6.70 |
ENST00000550563.1 ENST00000546370.1 |
DCN |
decorin |
| chr12_-_91573249 | 6.63 |
ENST00000550099.1 ENST00000546391.1 ENST00000551354.1 |
DCN |
decorin |
| chr12_-_91573316 | 6.00 |
ENST00000393155.1 |
DCN |
decorin |
| chr1_-_153517473 | 5.73 |
ENST00000368715.1 |
S100A4 |
S100 calcium binding protein A4 |
| chr8_-_13134045 | 5.69 |
ENST00000512044.2 |
DLC1 |
deleted in liver cancer 1 |
| chr2_-_163099885 | 5.44 |
ENST00000443424.1 |
FAP |
fibroblast activation protein, alpha |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 25.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.9 | 24.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 11.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 6.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 5.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 4.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 4.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 4.1 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 2.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 19.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 13.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 11.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 11.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.5 | 10.7 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.2 | 8.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 8.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.4 | 7.0 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.6 | 6.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 23.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 15.9 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 1.5 | 11.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 1.0 | 11.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 2.7 | 10.7 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 2.5 | 9.8 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 1.0 | 9.1 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.1 | 7.4 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 1.1 | 6.7 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 1.6 | 6.3 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 28.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.4 | 20.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 16.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 15.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 10.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 7.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 37.3 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.0 | 19.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 14.8 | GO:0005604 | basement membrane(GO:0005604) |
| 1.2 | 11.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 1.0 | 10.7 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 3.3 | 9.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 9.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 8.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 8.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.5 | 6.9 | GO:0030478 | actin cap(GO:0030478) |