ISMARA results: NFE2L1

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ENCODE cell lines, expression (Ernst 2011)

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Results for NFE2L1

Z-value: 1.27

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Transcription factors associated with NFE2L1

Gene Symbol	Gene ID	Gene Info
NFE2L1 Ensembl NCBI GeneCards UniProt	ENSG00000082641.11	NFE2L1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFE2L1	hg19_v2_chr17_+_46126135_46126152	0.18	5.0e-01	Click!

Activity profile of NFE2L1 motif

Sorted Z-values of NFE2L1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFE2L1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_52887034	6.88	ENST00000330722.6	KRT6A	keratin 6A
chr11_+_35201826	3.10	ENST00000531873.1	CD44	CD44 molecule (Indian blood group)
chr11_+_35211511	3.08	ENST00000524922.1	CD44	CD44 molecule (Indian blood group)
chr2_-_113594279	3.04	ENST00000416750.1 ENST00000418817.1 ENST00000263341.2	IL1B	interleukin 1, beta
chr11_+_35198243	2.92	ENST00000528455.1	CD44	CD44 molecule (Indian blood group)
chr11_+_35198118	2.55	ENST00000525211.1 ENST00000526000.1 ENST00000279452.6 ENST00000527889.1	CD44	CD44 molecule (Indian blood group)
chr12_-_15103621	2.32	ENST00000536592.1	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr11_+_35211429	2.30	ENST00000525688.1 ENST00000278385.6 ENST00000533222.1	CD44	CD44 molecule (Indian blood group)
chr2_+_234602305	2.28	ENST00000406651.1	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_-_125366089	2.20	ENST00000366139.3 ENST00000278919.3	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.6	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	7.6	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	7.4	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.2	4.8	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4	4.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2	3.6	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	2.9	GO:0044325	ion channel binding(GO:0044325)
0.5	2.1	GO:0035651	AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2	2.1	GO:0045545	syndecan binding(GO:0045545)
0.6	1.9	GO:0008859	exoribonuclease II activity(GO:0008859)

Showing 1 to 10 of 84 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	17.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	4.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	2.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	2.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.6	PID FGF PATHWAY	FGF signaling pathway
0.0	1.4	PID INSULIN PATHWAY	Insulin Pathway
0.0	1.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.9	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	13.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	4.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	3.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	3.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	2.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	2.3	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	1.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.5	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	1.4	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	1.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins

Showing 1 to 10 of 31 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	13.9	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1	6.6	GO:0045095	keratin filament(GO:0045095)
0.0	5.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.4	2.1	GO:0031905	early endosome lumen(GO:0031905)
0.1	2.0	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.6	1.9	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.2	1.9	GO:0005614	interstitial matrix(GO:0005614)
0.2	1.8	GO:0000322	storage vacuole(GO:0000322)
0.1	1.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.4	1.5	GO:0031673	H zone(GO:0031673)

Showing 1 to 10 of 51 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	13.9	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.7	9.6	GO:0052696	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
2.3	6.9	GO:0051710	regulation of cytolysis in other organism(GO:0051710)
0.0	4.6	GO:1900181	negative regulation of protein localization to nucleus(GO:1900181)
1.1	4.5	GO:0071461	cellular response to redox state(GO:0071461)
1.0	3.0	GO:0070487	monocyte aggregation(GO:0070487)
0.4	2.2	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.7	2.1	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.4	2.0	GO:0030047	actin modification(GO:0030047)
0.3	2.0	GO:1903232	melanosome assembly(GO:1903232)

Showing 1 to 10 of 127 entries

Results for NFE2L1

Z-value: 1.27

Motif logo

Transcription factors associated with NFE2L1

Activity-expression correlation:

Activity profile of NFE2L1 motif

Sorted Z-values of NFE2L1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFE2L1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category: