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ENCODE cell lines, expression (Ernst 2011)
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Results for NFIL3
Z-value: 1.39
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Transcription factors associated with NFIL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIL3 | hg19_v2_chr9_-_94186131_94186174 | 0.74 | 1.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIL3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_69962185 | 8.85 |
ENST00000305231.7 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr4_+_69962212 | 8.04 |
ENST00000508661.1 |
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
| chr10_-_5046042 | 7.18 |
ENST00000421196.3 ENST00000455190.1 |
AKR1C2 |
aldo-keto reductase family 1, member C2 |
| chr4_+_69681710 | 6.05 |
ENST00000265403.7 ENST00000458688.2 |
UGT2B10 |
UDP glucuronosyltransferase 2 family, polypeptide B10 |
| chr10_+_5005598 | 5.04 |
ENST00000442997.1 |
AKR1C1 |
aldo-keto reductase family 1, member C1 |
| chr10_+_5005445 | 4.68 |
ENST00000380872.4 |
AKR1C1 |
aldo-keto reductase family 1, member C1 |
| chr4_+_74275057 | 3.30 |
ENST00000511370.1 |
ALB |
albumin |
| chr1_-_230850043 | 3.22 |
ENST00000366667.4 |
AGT |
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| chr2_+_11674213 | 3.13 |
ENST00000381486.2 |
GREB1 |
growth regulation by estrogen in breast cancer 1 |
| chr3_+_186330712 | 3.09 |
ENST00000411641.2 ENST00000273784.5 |
AHSG |
alpha-2-HS-glycoprotein |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 25.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 5.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 3.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 3.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 3.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 3.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 25.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 2.8 | 16.9 | GO:0047115 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.4 | 5.3 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.3 | 5.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 4.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 4.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.4 | 4.0 | GO:0008430 | selenium binding(GO:0008430) |
| 0.3 | 4.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.5 | 3.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 3.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 17.2 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.7 | 15.8 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 1.6 | 6.6 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.8 | 5.1 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.4 | 4.9 | GO:0000050 | urea cycle(GO:0000050) |
| 0.8 | 4.8 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.3 | 4.8 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 4.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 1.3 | 4.0 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.2 | 4.0 | GO:0006907 | pinocytosis(GO:0006907) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 6.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 3.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.6 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.4 | 6.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 5.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 5.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 5.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.6 | 4.8 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.0 | 4.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 3.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 3.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.2 | 3.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |