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ENCODE cell lines, expression (Ernst 2011)
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Results for NFKB1
Z-value: 1.89
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103423055_103423112 | 0.68 | 3.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_149792295 | 9.70 |
ENST00000518797.1 ENST00000524315.1 ENST00000009530.7 ENST00000377795.3 |
CD74 |
CD74 molecule, major histocompatibility complex, class II invariant chain |
| chr19_-_6591113 | 6.93 |
ENST00000423145.3 ENST00000245903.3 |
CD70 |
CD70 molecule |
| chr14_+_75988851 | 6.56 |
ENST00000555504.1 |
BATF |
basic leucine zipper transcription factor, ATF-like |
| chr6_+_14117872 | 6.08 |
ENST00000379153.3 |
CD83 |
CD83 molecule |
| chr6_+_32605134 | 5.70 |
ENST00000343139.5 ENST00000395363.1 ENST00000496318.1 |
HLA-DQA1 |
major histocompatibility complex, class II, DQ alpha 1 |
| chr6_+_138188551 | 5.70 |
ENST00000237289.4 ENST00000433680.1 |
TNFAIP3 |
tumor necrosis factor, alpha-induced protein 3 |
| chr6_+_32605195 | 5.70 |
ENST00000374949.2 |
HLA-DQA1 |
major histocompatibility complex, class II, DQ alpha 1 |
| chr11_+_102188272 | 5.65 |
ENST00000532808.1 |
BIRC3 |
baculoviral IAP repeat containing 3 |
| chr6_-_29527702 | 5.64 |
ENST00000377050.4 |
UBD |
ubiquitin D |
| chr11_+_102188224 | 5.62 |
ENST00000263464.3 |
BIRC3 |
baculoviral IAP repeat containing 3 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 14.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.6 | 11.4 | GO:0042611 | MHC protein complex(GO:0042611) |
| 1.4 | 9.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.4 | 9.5 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 9.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.7 | 7.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 6.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 6.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 6.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 5.6 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.5 | 11.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 10.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 9.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 9.5 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 9.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 7.8 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.7 | 7.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 6.9 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.1 | 5.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 32.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 8.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 8.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 7.7 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.3 | 7.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 5.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 4.7 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.2 | 4.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 3.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.2 | 12.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.9 | 11.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 10.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 10.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 10.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.9 | 9.7 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 1.4 | 8.2 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.7 | 8.2 | GO:0004568 | chitinase activity(GO:0004568) chitin binding(GO:0008061) |
| 0.1 | 6.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.1 | 11.9 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 1.3 | 11.3 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.7 | 10.7 | GO:0060263 | regulation of respiratory burst(GO:0060263) |
| 0.5 | 10.3 | GO:0072540 | T-helper 17 cell lineage commitment(GO:0072540) |
| 1.9 | 9.7 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.1 | 8.9 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.7 | 8.2 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.7 | 7.4 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 2.2 | 6.5 | GO:1990108 | protein linear deubiquitination(GO:1990108) |