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ENCODE cell lines, expression (Ernst 2011)
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Results for NR1I2
Z-value: 1.73
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Transcription factors associated with NR1I2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1I2 | hg19_v2_chr3_+_119501557_119501557 | -0.33 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91576429 | 7.20 |
ENST00000552145.1 ENST00000546745.1 |
DCN |
decorin |
| chr11_+_117073850 | 5.87 |
ENST00000529622.1 |
TAGLN |
transgelin |
| chr3_+_157154578 | 5.43 |
ENST00000295927.3 |
PTX3 |
pentraxin 3, long |
| chr1_-_151965048 | 5.11 |
ENST00000368809.1 |
S100A10 |
S100 calcium binding protein A10 |
| chr15_+_39873268 | 5.00 |
ENST00000397591.2 ENST00000260356.5 |
THBS1 |
thrombospondin 1 |
| chrX_+_135278908 | 4.43 |
ENST00000539015.1 ENST00000370683.1 |
FHL1 |
four and a half LIM domains 1 |
| chr11_-_111783595 | 4.08 |
ENST00000528628.1 |
CRYAB |
crystallin, alpha B |
| chrX_+_135279179 | 4.02 |
ENST00000370676.3 |
FHL1 |
four and a half LIM domains 1 |
| chr5_+_125695805 | 4.01 |
ENST00000513040.1 |
GRAMD3 |
GRAM domain containing 3 |
| chr7_+_134576151 | 3.69 |
ENST00000393118.2 |
CALD1 |
caldesmon 1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 10.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 9.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 4.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 2.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 11.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 5.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 4.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 3.8 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 3.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 3.3 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 2.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 2.8 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 13.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 11.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 7.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 7.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.4 | 6.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 5.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.4 | 5.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.4 | 5.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 4.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 4.1 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 16.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 7.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 6.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 5.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 1.7 | 5.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.6 | 5.0 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 4.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 3.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 3.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 13.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 10.3 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.4 | 6.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 5.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.7 | 5.1 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 5.1 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 1.7 | 5.0 | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation(GO:0002605) |
| 1.0 | 5.0 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 1.2 | 4.8 | GO:0009956 | radial pattern formation(GO:0009956) |
| 1.5 | 4.5 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |