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ENCODE cell lines, expression (Ernst 2011)
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Results for NRF1
Z-value: 2.64
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | 0.94 | 1.1e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_65029421 | 3.84 |
ENST00000541089.1 |
POLA2 |
polymerase (DNA directed), alpha 2, accessory subunit |
| chr1_+_91966384 | 3.55 |
ENST00000430031.2 ENST00000234626.6 |
CDC7 |
cell division cycle 7 |
| chr6_-_41040195 | 3.52 |
ENST00000463088.1 ENST00000469104.1 ENST00000486443.1 |
OARD1 |
O-acyl-ADP-ribose deacylase 1 |
| chr17_-_57970074 | 3.47 |
ENST00000346141.6 |
TUBD1 |
tubulin, delta 1 |
| chr6_-_41040268 | 3.25 |
ENST00000373154.2 ENST00000244558.9 ENST00000464633.1 ENST00000424266.2 ENST00000479950.1 ENST00000482515.1 |
OARD1 |
O-acyl-ADP-ribose deacylase 1 |
| chr1_+_91966656 | 3.25 |
ENST00000428239.1 ENST00000426137.1 |
CDC7 |
cell division cycle 7 |
| chr21_-_33651324 | 3.13 |
ENST00000290130.3 |
MIS18A |
MIS18 kinetochore protein A |
| chr6_+_135502408 | 2.77 |
ENST00000341911.5 ENST00000442647.2 ENST00000316528.8 |
MYB |
v-myb avian myeloblastosis viral oncogene homolog |
| chr6_+_24403144 | 2.75 |
ENST00000274747.7 ENST00000543597.1 ENST00000535061.1 ENST00000378353.1 ENST00000378386.3 ENST00000443868.2 |
MRS2 |
MRS2 magnesium transporter |
| chr6_+_135502466 | 2.71 |
ENST00000367814.4 |
MYB |
v-myb avian myeloblastosis viral oncogene homolog |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.3 | 12.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 12.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.8 | 11.3 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.3 | 10.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 7.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 6.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 6.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 6.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 6.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 7.4 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 7.3 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.6 | 6.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 6.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 6.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.5 | 6.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.6 | 6.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.2 | 5.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 5.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 12.6 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 0.1 | 10.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.8 | 9.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.5 | 8.9 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.3 | 8.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 7.2 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 6.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 6.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.7 | 5.8 | GO:0031931 | TORC1 complex(GO:0031931) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.2 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.2 | 8.5 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.3 | 8.0 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.2 | 7.0 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.1 | 6.9 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.8 | 6.8 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 2.2 | 6.7 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 6.7 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 6.7 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
| 0.1 | 6.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 7.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 6.5 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.3 | 5.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 5.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 5.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 5.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 4.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 4.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |