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ENCODE cell lines, expression (Ernst 2011)
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Results for ONECUT1
Z-value: 1.19
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Transcription factors associated with ONECUT1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT1 | hg19_v2_chr15_-_53082178_53082209 | 0.84 | 4.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ONECUT1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_46679144 | 6.10 |
ENST00000181383.4 |
CPB2 |
carboxypeptidase B2 (plasma) |
| chr13_-_46679185 | 5.85 |
ENST00000439329.3 |
CPB2 |
carboxypeptidase B2 (plasma) |
| chr9_-_116840728 | 5.77 |
ENST00000265132.3 |
AMBP |
alpha-1-microglobulin/bikunin precursor |
| chr12_+_69742121 | 4.85 |
ENST00000261267.2 ENST00000549690.1 ENST00000548839.1 |
LYZ |
lysozyme |
| chrX_-_131623982 | 3.75 |
ENST00000370844.1 |
MBNL3 |
muscleblind-like splicing regulator 3 |
| chr17_-_64225508 | 3.67 |
ENST00000205948.6 |
APOH |
apolipoprotein H (beta-2-glycoprotein I) |
| chr19_+_45449228 | 3.62 |
ENST00000252490.4 |
APOC2 |
apolipoprotein C-II |
| chr1_+_207262881 | 3.55 |
ENST00000451804.2 |
C4BPB |
complement component 4 binding protein, beta |
| chr19_+_45449301 | 3.54 |
ENST00000591597.1 |
APOC2 |
apolipoprotein C-II |
| chr19_+_45449266 | 3.20 |
ENST00000592257.1 |
APOC2 |
apolipoprotein C-II |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | ST GAQ PATHWAY | G alpha q Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 10.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 4.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 4.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.0 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 2.0 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 1.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 1.3 | 10.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 4.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 3.7 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 2.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.5 | 2.2 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 2.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 2.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 1.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.9 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 14.0 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.4 | 11.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.4 | 5.8 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 5.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.8 | 4.9 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.2 | 2.4 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 2.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 2.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.5 | 2.0 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.3 | 1.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 12.4 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 3.0 | 11.9 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 3.5 | 10.4 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 0.4 | 5.8 | GO:0006787 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 1.0 | 4.9 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 3.8 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 1.0 | 3.1 | GO:0045013 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 0.3 | 3.0 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.1 | 2.6 | GO:0035413 | positive regulation of catenin import into nucleus(GO:0035413) |
| 0.4 | 2.4 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |