ISMARA results: PBX3

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ENCODE cell lines, expression (Ernst 2011)

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Results for PBX3

Z-value: 1.40

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Transcription factors associated with PBX3

Gene Symbol	Gene ID	Gene Info
PBX3 Ensembl NCBI GeneCards UniProt	ENSG00000167081.12	PBX3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PBX3	hg19_v2_chr9_+_128509663_128509733	0.10	7.0e-01	Click!

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_89238149	6.58	ENST00000289746.2	CDH15	cadherin 15, type 1, M-cadherin (myotubule)
chr2_-_179672142	4.41	ENST00000342992.6 ENST00000360870.5 ENST00000460472.2 ENST00000589042.1 ENST00000591111.1 ENST00000342175.6 ENST00000359218.5	TTN	titin
chr11_-_2170786	2.78	ENST00000300632.5	IGF2	insulin-like growth factor 2 (somatomedin A)
chr2_-_45236540	2.34	ENST00000303077.6	SIX2	SIX homeobox 2
chr9_-_35689900	2.13	ENST00000378300.5 ENST00000329305.2 ENST00000360958.2	TPM2	tropomyosin 2 (beta)
chr17_-_1619535	2.08	ENST00000573075.1 ENST00000574306.1	MIR22HG	MIR22 host gene (non-protein coding)
chrX_+_100805496	2.06	ENST00000372829.3	ARMCX1	armadillo repeat containing, X-linked 1
chr3_+_8775466	2.04	ENST00000343849.2 ENST00000397368.2	CAV3	caveolin 3
chr17_-_1619491	1.99	ENST00000570416.1 ENST00000575626.1 ENST00000610106.1 ENST00000608198.1 ENST00000609442.1 ENST00000334146.3 ENST00000576489.1 ENST00000608245.1 ENST00000609398.1 ENST00000608913.1 ENST00000574016.1 ENST00000571091.1 ENST00000573127.1 ENST00000609990.1 ENST00000576749.1	MIR22HG	MIR22 host gene (non-protein coding)
chrX_-_100914781	1.90	ENST00000431597.1 ENST00000458024.1 ENST00000413506.1 ENST00000440675.1 ENST00000328766.5 ENST00000356824.4	ARMCX2	armadillo repeat containing, X-linked 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.5	GO:0051149	positive regulation of muscle cell differentiation(GO:0051149)
1.6	6.4	GO:0035995	detection of muscle stretch(GO:0035995)
1.2	3.5	GO:0002663	B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.6	2.8	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
0.3	2.8	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	2.7	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.8	2.3	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	2.3	GO:0008360	regulation of cell shape(GO:0008360)
0.2	2.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	2.1	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Showing 1 to 10 of 116 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.3	GO:0031594	neuromuscular junction(GO:0031594)
0.1	4.3	GO:0005859	muscle myosin complex(GO:0005859)
0.1	4.2	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	4.2	GO:0031091	platelet alpha granule(GO:0031091)
0.4	3.5	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3	2.8	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	2.7	GO:0031225	anchored component of membrane(GO:0031225)
0.2	2.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	2.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	2.0	GO:0043197	dendritic spine(GO:0043197)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.3	GO:0005509	calcium ion binding(GO:0005509)
0.4	4.4	GO:0031433	telethonin binding(GO:0031433)
0.9	3.5	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.1	2.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.2	2.6	GO:0043295	glutathione binding(GO:0043295)
0.0	2.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	2.2	GO:0001618	virus receptor activity(GO:0001618)
0.3	2.0	GO:0071253	connexin binding(GO:0071253)
0.1	1.9	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	1.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	3.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	3.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	3.0	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.1	2.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.7	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	2.7	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	1.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.6	PID FGF PATHWAY	FGF signaling pathway
0.0	2.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	2.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	2.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	2.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.6	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.0	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.9	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 10 of 16 entries

Results for PBX3

Z-value: 1.40

Motif logo

Transcription factors associated with PBX3

Activity-expression correlation:

Activity profile of PBX3 motif

Sorted Z-values of PBX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category: